Fish Oil (SMOFlipid) and olive oil lipid (Clinoleic) in very preterm neonates
Deshpande G, Simmer K, Deshmukh M, Mori TA, Croft KD, Kristensen J
Journal of pediatric gastroenterology and nutrition · 59 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2013-09-17 · J Pediatr Gastroenterol Nutr · vol. 58 · issue 2 · pp. 177–182
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 88 citations · more than 94% of similar papers · 4.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 35 works
- Access
- Paywalled
- Research areas
- Neonatal Respiratory Health Research · Infant Nutrition and Health · Clinical Nutrition and Gastroenterology
- Keywords
- Docosahexaenoic acid, Fish oil, Polyunsaturated fatty acid, Eicosapentaenoic acid, Soybean oil, Medicine, Food science, Linoleic acid, Fatty acid, Lipid peroxidation, Internal medicine, Biochemistry, Oxidative stress, Chemistry, Biology, Fishery, Fish <Actinopterygii>
- MeSH
- humans, vitamin e, docosahexaenoic acids, eicosapentaenoic acid, soybean oil, fat emulsions, intravenous, fatty acids, unsaturated, f2-isoprostanes, linoleic acid, oleic acid, fish oils, plant oils, parenteral nutrition, total, lipid peroxidation, oxidative stress, infant, newborn, female, male, infant, extremely premature, olive oil, coconut oil
6 authors
From AU
- Girish C. Deshpande · correspondingKing Edward Memorial Hospital
- Karen Norrie Simmer · correspondingKing Edward Memorial Hospital
- Mangesh Deshmukh · correspondingKing Edward Memorial Hospital
- Trevor Anthony MoriThe University of Western Australia
- Kevin D. CroftThe University of Western Australia
- Judy KristensenKing Edward Memorial Hospital
Abstract
Objectives
Fat emulsions used in Australia for parenteral nutrition in preterm neonates have been based on either soybean oil or olive oil (OO). OO lipid Clinoleic has a high ratio of n-6 to n-3 fatty acids (9:1); this may not be ideal for long-chain polyunsaturated fatty acids supply. Newly available SMOFlipid has an appropriate ratio of n-6 to n-3 fatty acids (2.5:1). SMOFlipid also contains OO (25%), coconut oil (30%), and soybean oil (30%). The aims of the study were to evaluate the safety of the SMOFlipid and to test the hypothesis that SMOFlipid would lead to increased omega-3 long-chain polyunsaturated fatty acid levels and reduced oxidative stress as compared with Clinoleic in preterm neonates (<30 weeks).
Methods
Preterm neonates (23-30 weeks) were randomised to receive Clinoleic or SMOFlipid emulsion for 7 days. Investigators and outcome assessors were masked to allocation. Plasma F2-isoprostanes (lipid peroxidation marker), red blood cell fatty acids, and vitamin E were measured before and after the study. Blood culture positive sepsis and growth were monitored for safety.
Results
Thirty of 34 participants completed the study. Both emulsions were well tolerated without any adverse events. F2-isoprostane levels were reduced in the SMOFlipid group as compared with baseline. Eicosapentanoic acid and vitamin E levels were significantly increased in the SMOFlipid group. Oleic acid and linoleic acid levels were increased in both groups. No significant differences were noted in poststudy docosahexaenoic acid levels in both groups despite higher levels of docosahexaenoic acid in SMOFlipid.
Conclusions
SMOFlipid was safe, well tolerated, and showed beneficial effect in terms of reduction of oxidative stress by reducing lipid peroxidation levels in high-risk preterm neonates.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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