Transcranial application of near-infrared low-level laser can modulate cortical excitability
Konstantinović LM, Jelić MB, Jeremić A, Stevanović VB, Milanović SD, Filipović SR
Lasers in surgery and medicine · 41 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- Science and Engineering Research Board
Based on 1 listed funder(s).
Publication
- Published
- 2013-10-17 · Lasers Surg Med · vol. 45 · issue 10 · pp. 648–653
- Publisher
- Wiley
- Cited
- 73 citations · more than 94% of similar papers · 4.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 31 works
- Access
- Paywalled
- Research areas
- Laser Applications in Dentistry and Medicine · Photoreceptor and optogenetics research · Transcranial Magnetic Stimulation Studies
- Keywords
- Transcranial magnetic stimulation, Motor cortex, Scalp, Stimulation, Cortex (anatomy), Cerebral cortex, Neuroscience, Motor area, Medicine, Evoked potential, Psychology, Anatomy
- MeSH
- motor cortex, humans, evoked potentials, motor, adult, middle aged, female, transcranial magnetic stimulation, healthy volunteers, low-level light therapy
6 authors
From RS
- Ljubica M. KonstantinovićUniversity of Belgrade
- Milan B. JelićUniversity of Belgrade
- A. Jeremic
- Vuk B. StevanovićUniversity of Belgrade
- S. MilanovićUniversity of Belgrade
- Saša R. Filipović · correspondingUniversity of Belgrade
Abstract
Background and objective
Near-infrared low-level laser (NIR-LLL) irradiation penetrates scalp and skull and can reach superficial layers of the cerebral cortex. It was shown to improve the outcome of acute stroke in both animal and human studies. In this study we evaluated whether transcranial laser stimulation (TLS) with NIR-LLL can modulate the excitability of the motor cortex (M1) as measured by transcranial magnetic stimulation (TMS).
Methods
TLS was applied for 5 minutes over the representation of the right first dorsal interosseal muscle (FDI) in left primary motor cortex (M1), in 14 healthy subjects. Motor evoked potentials (MEPs) from the FDI, elicited by single-pulse TMS, were measured at baseline and up to 30 minutes after the TLS.
Results
The average MEP size was significantly reduced during the first 20 minutes following the TLS. The pattern was present in 10 (71.5%) of the participants. The MEP size reduction correlated negatively with the motor threshold at rest.
Conclusions
TLS with NIR-LLL induced transitory reduction of the excitability of the stimulated cortex. These findings give further insights into the mechanisms of TLS effects in the human cerebral cortex, paving the way for potential applications of TLS in treatment of stroke and in other clinical settings.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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