Red meat-derived heterocyclic amines increase risk of colon cancer: a population-based case-control study
Helmus DS, Thompson CL, Zelenskiy S, Tucker TC, Li L
Nutrition and cancer · 49 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Damon Runyon Cancer Research Foundation
- University or hospital
- University of Arizona Cancer Center
- University or hospital
- University of Kentucky
- Government
- National Institutes of Health
- Government
- National Cancer Institute
- Government
- NCI NIH HHS
- Grants
- National Cancer Institute (R01-CA136726)
Based on 6 listed funder(s).
Publication
- Published
- 2013-10-29 · Nutr Cancer · vol. 65 · issue 8 · pp. 1141–1150
- Publisher
- Routledge
- Cited
- 65 citations · more than 82% of similar papers · 1.6× the field average
- References
- 37 works
- Access
- Open access (repository copy)
- Research areas
- Carcinogens and Genotoxicity Assessment · Indoor Air Quality and Microbial Exposure · Synthesis and Biological Evaluation
- Keywords
- Red meat, Colorectal cancer, Odds ratio, Quartile, Mutagen, White meat, Medicine, Confidence interval, Population, Cancer, Food science, Processed meat, Case-control study, Carcinogen, Chemistry, Internal medicine, Environmental health, Biochemistry
- MeSH
- humans, colonic neoplasms, amines, quinoxalines, mutagens, nutrition assessment, confidence intervals, logistic models, odds ratio, risk factors, case-control studies, meat, aged, middle aged, female, male, cooking, surveys and questionnaires, polycyclic aromatic hydrocarbons
5 authors
From US
- Drew S. HelmusCase Western Reserve University
- Cheryl L. ThompsonCase Western Reserve University
- Svetlana ZelenskiyCase Western Reserve University
- Thomas C. TuckerUniversity of Kentucky
- Li LiCase Western Reserve University
Abstract
Formation of mutagenic heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) is one pathway believed to drive the association of colon cancer with meat consumption. Limited data exist on the associations of individual HCAs and PAHs in red or white meat with colon cancer. Analyzing data from a validated meat preparation questionnaire completed by 1062 incident colon cancer cases and 1645 population controls from an ongoing case-control study, risks of colon cancer were estimated using unconditional logistic regression models, comparing the fourth to the first quartile of mutagen estimates derived from a CHARRED based food frequency questionnaire. Total dietary intake of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) [adjusted odds ratio (aOR) = 1.87, 95% confidence interval (CI) = 1.44-2.44, P(trend) < 0.0001], 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) (aOR = 1.68, 95% CI = 1.29-2.17, P(trend) = 0.001) and meat-derived mutagenic activity (aOR = 1.77, 95% CI = 1.36-2.30, P(trend) < 0.0001) were statistically significantly associated with colon cancer risk. Meat type specific analyses revealed statistically significant associations for red meat-derived MeIQx, DiMeIQx, and mutagenic activity but not for the same mutagens derived from white meat. Our study adds evidence supporting red meat-derived, but not white-meat derived HCAs and PAHs, as an important pathway for environmental colon cancer carcinogenesis.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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