Physical inactivity, water intake and constipation as risk factors for colorectal cancer among adults in Jordan
Tayyem RF, Shehadeh IN, Abumweis SS, Bawadi HA, Hammad SS, Bani-Hani KE, Al-Jaberi TM, Alnusair MM
Asian Pacific journal of cancer prevention : APJCP · 22 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2013-09-30 · Asian Pac J Cancer Prev · vol. 14 · issue 9 · pp. 5207–5212
- Publisher
- West Asia Organization for Cancer Prevention
- Cited
- 31 citations · more than 88% of similar papers · 2.2× the field average
- References
- 39 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Physical Activity and Health · Nutritional Studies and Diet · Cancer Risks and Factors
- Keywords
- Medicine, Colorectal cancer, Constipation, Physical activity, Internal medicine, Case-control study, Population, Cancer, Body mass index, Risk factor, Gastroenterology, Physical therapy, Environmental health
- MeSH
- humans, colorectal neoplasms, constipation, body mass index, exercise, risk factors, case-control studies, motor activity, age factors, drinking, middle aged, jordan, female, male, protective factors, sedentary behavior
8 authors
From JO
- Reema TayyemHashemite University
- Ihab Shehadeh
- Suhad Sameer AbuMweis
- Hiba Ahmad Bawadi
- Shatha Sabri Hammad
- Kamal Eddin Bani-Hani
Abstract
Background
Physical activity has been found to play a role in cancer prevention. The purpose of this matched case-control study was to investigate the association between physical activity levels, water intake, constipation and colorectal cancer (CRC).
Materials and methods
Two hundred and thirty-two patients diagnosed with CRC (125 male, 107 female) were enrolled in this case-control study. Cases were matched to 271 population controls (137 male, 134 female).
Results
Drinking more than 4 cups of water daily decreased the risk of CRC by 33-42%; however, this effect was non-significant. Having constipation was found to be a significant risk factor for developing CRC with an OR=6.284 (95%CI=2.741-14.40). With reference to sedentary behavior, minimum activity (600-3000 Metabolic Equivalents Task (MET)) had 43% protection against CRC and the level of Health Enhancing Physical Activity OR was 0.58 (at 95%CI; 0.37-0.92). A significant negative association was found between CRC and physical activity levels expressed as both METs and MET-hours/week (p for trend=0.017 and 0.03, respectively). Among females, a significant trend of reduction in CRC by 62% was observed with increasing the level of physical activity expressed in MET (p for trend=0.04).
Conclusions
The risk of CRC may be reduced by adopting a healthy lifestyle and practicing physically activity regularly, especially among females. Consuming adequate amounts of water and healthy bowel motility could also reduce the risk of CRC.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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