Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer
Jeyabalan J, Aqil F, Munagala R, Annamalai L, Vadhanam MV, Gupta RC
Journal of agricultural and food chemistry · 55 citations
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Cancer Institute
- Government
- NCI NIH HHS
- Grants
- National Cancer Institute (CA-125152); National Cancer Institute (CA-118114)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2013-11-18 · J Agric Food Chem · vol. 62 · issue 18 · pp. 3963–3971
- Publisher
- American Chemical Society
- Cited
- 80 citations · more than 81% of similar papers · 1.6× the field average
- References
- 49 works
- Access
- Open access (hybrid journal) · OTHER-OA
- Research areas
- Phytochemicals and Antioxidant Activities · Bioactive Compounds in Plants · Garlic and Onion Studies
- Keywords
- Carcinogenesis, Estrogen, Breast cancer, Therapeutic effect, Medicine, Mammary tumor, Internal medicine, Cancer research, Mammary gland, Oncology, Cancer, Endocrinology, Physiology
- MeSH
- animals, rats, inbred aci, humans, rats, fruit, breast neoplasms, estradiol, cytochrome p-450 cyp1a1, estrogen receptor alpha, micrornas, estrogens, female, blueberry plants
6 authors
From US
- Jeyaprakash JeyabalanUniversity of Louisville; University of Louisville Hospital
- Farrukh AqilUniversity of Louisville; University of Louisville Hospital
- Radha MunagalaUniversity of Louisville; University of Louisville Hospital
- Lakshmanan AnnamalaiUniversity of Louisville; University of Louisville Hospital
- Manicka V. VadhanamUniversity of Louisville; University of Louisville Hospital
- Ramesh Chand Gupta · correspondingUniversity of Louisville; University of Louisville Hospital
Abstract
Berries are gaining increasing importance lately for their chemopreventive and therapeutic potential against several cancers. In earlier studies, a blueberry-supplemented diet has shown protection against 17β-estradiol (E2)-mediated mammary tumorigenesis. This study tested both preventive and therapeutic activities of diet supplemented with whole blueberry powder (50:50 blend of Tifblue and Rubel). Animals received 5% blueberry diet, either 2 weeks prior to or 12 weeks after E2 treatment in preventive and therapeutic groups, respectively. Both interventions delayed the tumor latency for palpable mammary tumors by 28 and 37 days, respectively. Tumor volume and multiplicity were also reduced significantly in both modes. The effect on mammary tumorigenesis was largely due to down-regulation of CYP 1A1 and ER-α gene expression and also favorable modulation of microRNA (miR-18a and miR-34c) levels. These data suggest that the blueberry blend tested is effective in inhibiting E2-mediated mammary tumorigenesis in both preventive and therapeutic modes.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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