Calorie intake, olive oil consumption and mammographic density among Spanish women
García-Arenzana N, Navarrete-Muñoz EM, Lope V, Moreo P, Vidal C, Laso-Pablos S, Ascunce N, Casanova-Gómez F, Sánchez-Contador C, Santamariña C, Aragonés N, Pérez Gómez B, Vioque J, Pollán M
International journal of cancer · 23 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Possibly industry funded
- Government
- Instituto de Salud Carlos III
- Government
- Spain's Health Research Fund (Fondo de Investigación Sanitaria)
- Company
- Collaboration Agreement between Astra-Zeneca and the Carlos III Institute of Health (Instituto de Salud Carlos III)
- Nonprofit
- Spanish Federation of Breast Cancer patients
- Grants
- Instituto de Salud Carlos III (EPY 1306/06)
Based on 4 listed funder(s).
Publication
- Published
- 2013-10-23 · Int J Cancer · vol. 134 · issue 8 · pp. 1916–1925
- Publisher
- Wiley
- Cited
- 38 citations · more than 77% of similar papers · 1.2× the field average
- References
- 57 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Global Cancer Incidence and Screening · Nutritional Studies and Diet · Cancer Risks and Factors
- Keywords
- Medicine, Odds ratio, Body mass index, Confidence interval, Confounding, Logistic regression, Demography, Breast cancer, Cross-sectional study, Population, Calorie, Animal science, Environmental health, Cancer, Internal medicine, Biology
- MeSH
- mammary glands, human, milk, animals, humans, breast neoplasms, plant oils, mammography, body mass index, diet, risk factors, cross-sectional studies, feeding behavior, energy intake, middle aged, spain, female, biomarkers, olive oil, surveys and questionnaires, breast density
14 authors
From ES
- Nicolás García‐ArenzanaInstituto de Salud Carlos III; Hospital Universitario Infanta Leonor
- Eva María Navarrete‐MuñozUniversitat de Miguel Hernández d'Elx; Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
- Virginia LopeInstituto de Salud Carlos III; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
- Pilar MoreoServicio Aragonés de Salud
- Carmen VidalInstitut Català d'Ornitologia; Institut Català d'Oncologia
- Soledad Laso‐PablosGeneralitat Valenciana; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Abstract
High mammographic density (MD) is one of the main risk factors for development of breast cancer. To date, however, relatively few studies have evaluated the association between MD and diet. In this cross-sectional study, we assessed the association between MD (measured using Boyd's semiquantitative scale with five categories: 75%) and diet (measured using a food frequency questionnaire validated in a Spanish population) among 3,548 peri- and postmenopausal women drawn from seven breast cancer screening programs in Spain. Multivariate ordinal logistic regression models, adjusted for age, body mass index (BMI), energy intake and protein consumption as well as other confounders, showed an association between greater calorie intake and greater MD [odds ratio (OR) = 1.23; 95% confidence interval (CI) = 1.10-1.38, for every increase of 500 cal/day], yet high consumption of olive oil was nevertheless found to reduce the prevalence of high MD (OR = 0.86;95% CI = 0.76-0.96, for every increase of 22 g/day in olive oil consumption); and, while greater intake of whole milk was likewise associated with higher MD (OR = 1.10; 95%CI 1.00-1.20, for every increase of 200 g/day), higher consumption of protein (OR = 0.89; 95% CI 0.80-1.00, for every increase of 30 g/day) and white meat (p for trend 0.041) was found to be inversely associated with MD. Our study, the largest to date to assess the association between diet and MD, suggests that MD is associated with modifiable dietary factors, such as calorie intake and olive oil consumption. These foods could thus modulate the prevalence of high MD, and important risk marker for breast cancer.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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