Whole grain intake and survival among Scandinavian colorectal cancer patients
Skeie G, Braaten T, Olsen A, Kyrø C, Tjønneland A, Nilsson LM, Landberg R, Lund E
Nutrition and cancer · 15 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- NordForsk
Based on 1 listed funder(s).
Publication
- Published
- 2013-11-25 · Nutr Cancer · vol. 66 · issue 1 · pp. 6–13
- Publisher
- Routledge
- Cited
- 23 citations · more than 88% of similar papers · 2.3× the field average
- References
- 32 works
- Access
- Paywalled
- Research areas
- Nutritional Studies and Diet · Colorectal Cancer Screening and Detection · Nutrition and Health in Aging
- Keywords
- Medicine, Colorectal cancer, Hazard ratio, Proportional hazards model, Rectum, Cancer, Confidence interval, Prospective cohort study, Cohort, Internal medicine, Cohort study, Population, Oncology, Demography, Environmental health
- MeSH
- humans, colorectal neoplasms, diet, proportional hazards models, risk factors, prospective studies, feeding behavior, life style, dietary fiber, aged, middle aged, female, male, scandinavian and nordic countries, edible grain
8 authors
From NO, DK, SE
- Guri Skeie
- Tonje BraatenUiT The Arctic University of Norway
- Anja OlsenDanish Cancer Society
- Cecilie KyrøDanish Cancer Society
- Anne Marie TjønnelandDanish Cancer Society
- Lena Maria NilssonUmeå University
Abstract
To our knowledge, no studies of associations between intake of whole grain (WHG) and survival of colorectal cancer have been published, despite evidence that dietary fiber, and to some extent WHG, are associated with lower risk of colorectal cancer. Scandinavia is an area where the WHG consumption traditionally is high. We performed a case-only (N = 1119) study in the Scandinavian HELGA cohort of pre-diagnosis WHG intake (total WHG, WHG wheat, WHG rye, and WHG oats) and survival of colorectal cancer. Cox regression analyses were used to study the associations, both in categorical and continuous models, stratified by location (proximal, distal, rectum) and country. No evidence of an association was found, neither for total WHG intake (hazard ratio = 1.32, 95% confidence interval: 0.88-1.97 lowest vs. highest tertile, adjusted for age at diagnosis, metastasis status, smoking, folate, margarine, and energy), nor for specific grains. Prediagnosis consumption of WHG does not seem to improve survival of colorectal cancer in subjects diagnosed within this prospective population-based Scandinavian cohort.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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