Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and incidence of colorectal cancer
Kyrø C, Olsen A, Landberg R, Skeie G, Loft S, Åman P, Leenders M, Dik VK, Siersema PD, Pischon T, Christensen J, Overvad K, Boutron-Ruault MC, Fagherazzi G, Cottet V, Kühn T, Chang-Claude J, Boeing H, Trichopoulou A, Bamia C, Trichopoulos D, Palli D, Krogh V, Tumino R, Vineis P, Panico S, Peeters PH, Weiderpass E, Bakken T, Åsli LA, Argüelles M, Jakszyn P, Sánchez MJ, Amiano P, Huerta JM, Barricarte A, Ljuslinder I, Palmqvist R, Khaw KT, Wareham N, Key TJ, Travis RC, Ferrari P, Freisling H, Jenab M, Gunter MJ, Murphy N, Riboli E, Tjønneland A, Bueno-de-Mesquita HB
Journal of the National Cancer Institute · 48 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Intake biomarkers
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Cancer Research UK
- Government
- National Institute for Health and Care Research
- Government
- Medical Research Council
- Government
- European Research Council
- Government
- National Institute for Health Research (NIHR)
- Grants
- Cancer Research UK (14136); National Institute for Health and Care Research (NF-SI-0512-10114); Cancer Research UK (16491)
Based on 5 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2013-12-07 · J Natl Cancer Inst · vol. 106 · issue 1 · p. djt352
- Publisher
- Oxford University Press
- Cited
- 84 citations · more than 96% of similar papers · 5.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 43 works
- Access
- Free to read
- Research areas
- Food composition and properties · Colorectal Cancer Screening and Detection · Nutritional Studies and Diet
- Keywords
- Colorectal cancer, Medicine, Incidence (geometry), Internal medicine, Cancer, Quartile, Confidence interval, Confounding, Gastroenterology, European Prospective Investigation into Cancer and Nutrition, Prospective cohort study, Oncology
- MeSH
- humans, triticum, colorectal neoplasms, resorcinols, body mass index, incidence, logistic models, odds ratio, risk factors, case-control studies, feeding behavior, aged, middle aged, europe, mediterranean region, female, male, scandinavian and nordic countries, biomarkers, secale
50 authors
- Cecilie Kyrø
- Anja Olsen
- Rikard Landberg
- Guri Skeie
- Steffen H Loft
- Per Åman
Abstract
Background
Few studies have investigated the association between whole-grain intake and colorectal cancer. Because whole-grain intake estimation might be prone to measurement errors, more objective measures (eg, biomarkers) could assist in investigating such associations.
Methods
The association between alkylresorcinols, biomarkers of whole-grain rye and wheat intake, and colorectal cancer incidence were investigated using prediagnostic plasma samples from colorectal cancer case patients and matched control subjects nested within the European Prospective Investigation into Cancer and Nutrition. We included 1372 incident colorectal cancer case patients and 1372 individual matched control subjects and calculated the incidence rate ratios (IRRs) for overall and anatomical subsites of colorectal cancer using conditional logistic regression adjusted for potential confounders. Regional differences (Scandinavia, the Mediterranean, Central Europe) were also explored.
Results
High plasma total alkylresorcinol concentration was associated with lower incidence of distal colon cancer; the adjusted incidence rate ratio of distal colon cancer for the highest vs lowest quartile of plasma total alkylresorcinols was 0.48 (95% confidence interval [CI] = 0.28 to 0.83). An inverse association between plasma total alkylresorcinol concentrations and colon cancer was found for Scandinavian participants (IRR per doubling = 0.83; 95% CI = 0.70 to 0.98). However, plasma total alkylresorcinol concentrations were not associated with overall colorectal cancer, proximal colon cancer, or rectal cancer. Plasma alkylresorcinols concentrations were associated with colon and distal colon cancer only in Central Europe and Scandinavia (ie, areas where alkylresorcinol levels were higher).
Conclusions
High concentrations of plasma alkylresorcinols were associated with a lower incidence of distal colon cancer but not with overall colorectal cancer, proximal colon cancer, and rectal cancer.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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