Cryotherapy in inflammatory rheumatic diseases: a systematic review
Guillot X, Tordi N, Mourot L, Demougeot C, Dugué B, Prati C, Wendling D
Expert review of clinical immunology · 76 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2013-12-18 · Expert Rev Clin Immunol · vol. 10 · issue 2 · pp. 281–294
- Publisher
- Taylor & Francis
- Cited
- 135 citations · more than 66% of similar papers · 1.3× the field average
- References
- 86 works
- Access
- Paywalled
- Research areas
- Exercise and Physiological Responses · Autoimmune and Inflammatory Disorders Research · Tendon Structure and Treatment
- Keywords
- Cryotherapy, Medicine, Rheumatoid arthritis, Cochrane Library, Arthritis, Randomized controlled trial, Therapeutic effect, Inflammation, Internal medicine, Surgery
- MeSH
- joints, animals, humans, rheumatic diseases, inflammation, anti-inflammatory agents, inflammation mediators, complementary therapies, cryotherapy, evidence-based medicine
7 authors
From FR
- Xavier Guillot · correspondingInserm; Centre Hospitalier Universitaire de Besançon; Université de Franche-Comté
- Nicolás TordiInserm; Université de Franche-Comté
- Laurent MourotInserm; Université de Franche-Comté
- Céline DemougeotInserm; Université de Franche-Comté
- Benoît DuguéUniversité de Poitiers
- Clément PratiInserm; Centre Hospitalier Universitaire de Besançon; Université de Franche-Comté
Abstract
The aim of this article was to review current evidence about cryotherapy in inflammatory rheumatic diseases (therapeutic and biological effects). For therapeutic effects, we performed a systematic review (PubMed, EMBASE, Cochrane Library, LILACS databases, unpublished data) and selected studies including non-operated and non-infected arthritic patients treated with local cryotherapy or whole-body cryotherapy. By pooling 6 studies including 257 rheumatoid arthritis (RA) patients, we showed a significant decrease in pain visual analogic scale (mm) and 28-joint disease activity score after chronic cryotherapy in RA patients. For molecular pathways, local cryotherapy induces an intrajoint temperature decrease, which might downregulate several mediators involved in joint inflammation and destruction (cytokines, cartilage-degrading enzymes, proangiogenic factors), but studies in RA are rare. Cryotherapy should be included in RA therapeutic strategies as an adjunct therapy, with potential corticosteroid and nonsteroidal anti-inflammatory drug dose-sparing effects. However, techniques and protocols should be more precisely defined in randomized controlled trials with stronger methodology.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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