Skin prick test and basophil reactivity to cetuximab in patients with IgE to alpha-gal and allergy to red meat
Michel S, Scherer K, Heijnen IA, Bircher AJ
Allergy · 37 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case report (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2013-12-26 · Allergy · vol. 69 · issue 3 · pp. 403–405
- Publisher
- Wiley
- Cited
- 53 citations · more than 91% of similar papers · 3.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 10 works
- Access
- Paywalled
- Research areas
- Food Allergy and Anaphylaxis Research · Contact Dermatitis and Allergies · Mast cells and histamine
- Keywords
- Basophil activation, Cetuximab, Medicine, Immunoglobulin E, Allergy, Basophil, Immunology, Milk allergy, Food allergy, Desensitization (medicine), Alpha (finance), Dermatology, Internal medicine, Antibody, Monoclonal antibody, Surgery, Receptor
- MeSH
- basophils, humans, drug hypersensitivity, anaphylaxis, food hypersensitivity, immunoglobulin e, allergens, skin tests, meat products, aged, middle aged, female, male, antibodies, monoclonal, humanized, cetuximab
4 authors
From CH
- S. MichelUniversity Hospital of Basel
- Kathrin SchererUniversity Hospital of Basel
- Ingmar HeijnenUniversity Hospital of Basel
- Andreas J. Bircher · correspondingUniversity Hospital of Basel
Abstract
Severe hypersensitivity reactions to red meat with delay of several hours in patients with IgE to alpha-gal (galactose-alpha-1,3-galactose) have been reported. The diagnosis of meat allergy is difficult, because of the limited sensitivity of skin prick tests and specific IgE tests to meat extracts. These circumstances have been explained by the delayed expression of alpha-gal due to digestive processes. Because of the low sensitivity of skin prick tests to meat, we studied the possibility to perform skin prick tests with cetuximab, which carries the alpha-gal epitope. Skin prick and intradermal tests with cetuximab were clearly positive in 2 of 2 patients. As a further diagnostic step, we performed basophil activation tests with cetuximab. Skin prick tests and basophil activation test using cetuximab may be a more sensitive alternative in patients with an assumed allergy to meat.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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