Funded in part by U.S. Highbush Blueberry Council
Blueberry supplementation improves memory in middle-aged mice fed a high-fat diet
Carey AN, Gomes SM, Shukitt-Hale B
Journal of agricultural and food chemistry · 53 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Industry group
- U.S. Highbush Blueberry Council
Based on 1 listed funder(s).
Publication
- Published
- 2014-01-21 · J Agric Food Chem · vol. 62 · issue 18 · pp. 3972–3978
- Publisher
- American Chemical Society
- Cited
- 71 citations · more than 98% of similar papers · 13.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 43 works
- Access
- Paywalled
- Research areas
- Medicinal Plants and Neuroprotection · Biochemical Analysis and Sensing Techniques · Olfactory and Sensory Function Studies
- Keywords
- Calorie, Low fat diet, Nutrient, Food science, Medicine, Biology, Animal science, Obesity, Endocrinology
- MeSH
- animals, mice, inbred c57bl, humans, mice, fruit, memory, energy intake, aging, male, diet, high-fat, blueberry plants
3 authors
From US
- Amanda N. Carey · correspondingTufts University; Agricultural Research Service; United States Department of Agriculture; Simmons University
- Stacey M. GomesTufts University; Agricultural Research Service; United States Department of Agriculture
- Barbara Shukitt‐HaleTufts University; Agricultural Research Service; United States Department of Agriculture
Abstract
Consuming a high-fat diet may result in behavioral deficits similar to those observed in aging animals. It has been demonstrated that blueberry supplementation can allay age-related behavioral deficits. To determine if supplementation of a high-fat diet with blueberries offers protection against putative high-fat diet-related declines, 9-month-old C57Bl/6 mice were maintained on low-fat (10% fat calories) or high-fat (60% fat calories) diets with and without 4% freeze-dried blueberry powder. Novel object recognition memory was impaired by the high-fat diet; after 4 months on the high-fat diet, mice spent 50% of their time on the novel object in the testing trial, performing no greater than chance performance. Blueberry supplementation prevented recognition memory deficits after 4 months on the diets, as mice on this diet spent 67% of their time on the novel object. After 5 months on the diets, mice consuming the high-fat diet passed through the platform location less often than mice on low-fat diets during probe trials on days 2 and 3 of Morris water maze testing, whereas mice consuming the high-fat blueberry diet passed through the platform location as often as mice on the low-fat diets. This study is a first step in determining if incorporating more nutrient-dense foods into a high-fat diet can allay cognitive dysfunction.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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