Whole-grain intake favorably affects markers of systemic inflammation in obese children: a randomized controlled crossover clinical trial
Hajihashemi P, Azadbakht L, Hashemipor M, Kelishadi R, Esmaillzadeh A
Molecular nutrition & food research · 49 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Food Security Research Center, IUMS, Isfahan, Iran
Based on 1 listed funder(s).
Publication
- Published
- 2014-01-30 · Mol Nutr Food Res · vol. 58 · issue 6 · pp. 1301–1308
- Publisher
- Wiley
- Cited
- 66 citations · more than 93% of similar papers · 3.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 39 works
- Access
- Paywalled
- Research areas
- Food composition and properties · Celiac Disease Research and Management · Nutritional Studies and Diet
- Keywords
- Systemic inflammation, Randomized controlled trial, Crossover study, Inflammation, Medicine, Internal medicine, Whole grains, Clinical trial, Crossover, Pathology, Biology, Food science, Placebo, Alternative medicine
- MeSH
- humans, obesity, inflammation, body weight, c-reactive protein, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, body mass index, cross-over studies, life style, energy intake, dietary fiber, adolescent, child, diet records, female, overweight, adipokines, waist circumference, biomarkers, edible grain
5 authors
From IR
- Parisa HajihashemiIsfahan University of Medical Sciences
- Leila AzadbakhtIsfahan University of Medical Sciences
- Mahin HashemiporIsfahan University of Medical Sciences
- Roya KelishadiIsfahan University of Medical Sciences
- Ahmad Esmaillzadeh · correspondingIsfahan University of Medical Sciences
Abstract
Scope
Whole-grain foods have been reported to affect serum levels of inflammatory cytokines. However, we are aware of no study examining the effect of whole-grain intake on inflammatory biomarkers among children. The present study aimed to determine the effect of whole-grain intake on serum levels of inflammatory biomarkers in overweight or obese children.
Methods and results
In this randomized crossover clinical trial, 44 overweight or obese girls aged 8-15 years participated. After a 2-week run-in period, subjects were randomly assigned to either whole-grain or control groups. Subjects in the whole-grain group were given a list of whole-grain foods and were asked to obtain half of their needed servings of grains from whole-grain foods each day for 6 weeks. Individuals in the control group were also given a list of whole-grain foods and were asked not to consume any of these foods during the intervention phase of the study. A 4-week washout period was applied following which subjects were crossed over to the alternate arm for an additional 6 weeks. Fasting blood samples were taken before and after each phase of the study to quantify markers of systemic inflammation. Mean age, weight, and BMI of study participants were 11.2 ± 1.49 years, 51.2 ± 10.2 kg, and 23.5 ± 2.5 kg/m(2) , respectively. No significant effect of whole-grain intake on weight and BMI was seen compared with the control group. We found a significant effect of whole-grain intake on serum levels of high-sensitive C-reactive protein (-21.8 versus +12.1%, p = 0.03), soluble intercellular adhesion molecule-1 (-28.4 versus +6.3%, p = 0.02), serum amyloid A (-17.4 versus +9.9%, p = 0.02), and leptin (-9.7 versus +39.2%, p = 0.02) after 6 weeks. A trend toward the significant effect of whole-grain intake on serum levels of soluble vascular cell adhesion molecule-1 (-36.2% versus -7.8%, p = 0.07) was also observed.
Conclusion
This study provides evidence supporting the beneficial effects of whole-grain foods on biomarkers of systemic inflammation in obese children.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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