Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities: a randomized trial (Sysdimet)
Lankinen M, Kolehmainen M, Jääskeläinen T, Paananen J, Joukamo L, Kangas AJ, Soininen P, Poutanen K, Mykkänen H, Gylling H, Orešič M, Jauhiainen M, Ala-Korpela M, Uusitupa M, Schwab U
PloS one · 54 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Government
- European Commission
- Government
- Academy of Finland
- Government
- Tekes
- University or hospital
- Kuopion Yliopistollinen Sairaala
- University or hospital
- Oulun Yliopisto
- Nonprofit
- Diabetestutkimussäätiö
- Government
- Medical Research Council
- Authors
- At least one author declares a financial tie to industry
- Grants
- European Commission (FOOD-CT-2005-514008); Oulun Yliopisto (137870); European Commission (FOOD-CT-2005); Academy of Finland (137870); Academy of Finland (118590); Academy of Finland (131460); Academy of Finland (257545); Academy of Finland (070014); Tekes (070014)
Based on 7 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2014-02-28 · PLoS One · vol. 9 · issue 2 · p. e90352
- Publisher
- Public Library of Science
- Cited
- 69 citations · more than 97% of similar papers · 6.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 68 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Food composition and properties · Nutritional Studies and Diet · Phytoestrogen effects and research
- Keywords
- Postprandial, Lipid metabolism, Lipid profile, Food science, Blood lipids, Internal medicine, Polyunsaturated fatty acid, Lipoprotein, Cholesterol, Insulin, Metabolic syndrome, Endocrinology, Chemistry, Biology, Medicine, Fatty acid, Biochemistry, Obesity
- MeSH
- animals, humans, vaccinium myrtillus, fatty acids, omega-3, fatty acids, omega-6, apolipoproteins, diet, particle size, fish products, adult, aged, middle aged, female, male, lipid metabolism, cholesterol, hdl, metabolome, edible grain, metabolic syndrome
15 authors
From FI, GB
- Maria Anneli Lankinen · correspondingUniversity of Eastern Finland
- Marjukka KolehmainenUniversity of Eastern Finland; VTT Technical Research Centre of Finland
- Tiina J. JääskeläinenUniversity of Eastern Finland
- Jussi PaananenUniversity of Eastern Finland
- Laura JoukamoUniversity of Eastern Finland
- Antti J. KangasUniversity of Oulu
Abstract
Objective
We studied the combined effects of wholegrain, fish and bilberries on serum metabolic profile and lipid transfer protein activities in subjects with the metabolic syndrome.
Methods
Altogether 131 subjects (40-70 y, BMI 26-39 kg/m(2)) with impaired glucose metabolism and features of the metabolic syndrome were randomized into three groups with 12-week periods according to a parallel study design. They consumed either: a) wholegrain and low postprandial insulin response grain products, fatty fish 3 times a week, and bilberries 3 portions per day (HealthyDiet), b) wholegrain and low postprandial insulin response grain products (WGED), or c) refined wheat breads as cereal products (Control). Altogether 106 subjects completed the study. Serum metabolic profile was studied using an NMR-based platform providing information on lipoprotein subclasses and lipids as well as low-molecular-weight metabolites.
Results
There were no significant differences in clinical characteristics between the groups at baseline or at the end of the intervention. Mixed model analyses revealed significant changes in lipid metabolites in the HealthyDiet group during the intervention compared to the Control group. All changes reflected increased polyunsaturation in plasma fatty acids, especially in n-3 PUFAs, while n-6 and n-7 fatty acids decreased. According to tertiles of changes in fish intake, a greater increase of fish intake was associated with increased concentration of large HDL particles, larger average diameter of HDL particles, and increased concentrations of large HDL lipid components, even though total levels of HDL cholesterol remained stable.
Conclusions
The results suggest that consumption of diet rich in whole grain, bilberries and especially fatty fish causes changes in HDL particles shifting their subclass distribution toward larger particles. These changes may be related to known protective functions of HDL such as reverse cholesterol transport and could partly explain the known protective effects of fish consumption against atherosclerosis.
Trial registration
The study was registered at ClinicalTrials.gov NCT00573781.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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