Effects of consumption of whole grain foods rich in lignans in healthy postmenopausal women with moderate serum cholesterol: a pilot study
Durazzo A, Carcea M, Adlercreutz H, Azzini E, Polito A, Olivieri L, Zaccaria M, Meneghini C, Maiani F, Bausano G, Martiri F, Samaletdin A, Fumagalli A, Raguzzini A, Venneria E, Foddai MS, Ciarapica D, Mauro B, Volpe F, Maiani G
International journal of food sciences and nutrition · 19 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2014-03-10 · Int J Food Sci Nutr · vol. 65 · issue 5 · pp. 637–645
- Publisher
- Taylor & Francis
- Cited
- 24 citations · more than 74% of similar papers · 1.0× the field average
- References
- 89 works
- Access
- Paywalled
- Research areas
- Phytoestrogen effects and research · Food composition and properties · Phytase and its Applications
- Keywords
- Whole grains, Crossover study, Medicine, Food science, Excretion, Cholesterol, Lignan, Lipid profile, Animal science, Physiology, Internal medicine, Chemistry, Biology, Botany
- MeSH
- humans, body weight, lignans, cholesterol, glutathione peroxidase, superoxide dismutase, tumor necrosis factor-alpha, interleukin-6, body mass index, diet, pilot projects, cross-over studies, double-blind method, postmenopause, blood pressure, middle aged, italy, female, interleukin-1beta, edible grain
20 authors
From IT, NL, FI
- Alessandra Durazzo · correspondingConsiglio per la ricerca in agricoltura e l’analisi dell’economia agraria; Food & Nutrition
- Marina CarceaConsiglio per la ricerca in agricoltura e l’analisi dell’economia agraria; Food & Nutrition
- Herman AdlercreutzUniversity of Helsinki
- Elena AzziniConsiglio per la ricerca in agricoltura e l’analisi dell’economia agraria; Food & Nutrition
- Angela PolitoConsiglio per la ricerca in agricoltura e l’analisi dell’economia agraria; Food & Nutrition
- Lorenza OlivieriASL Roma; Azienda Sanitaria Locale Roma 3
Abstract
This study aims at investigating the effect of an experimental period of intake of whole grain foods rich in lignans as part of an habitual diet on the plasma and urinary excretion of enterolignans, the biomarkers of lipid metabolism and the immunological and antioxidant status in a group of postmenopausal women with moderate serum cholesterol. A randomized double-blind crossover study was completed on 13 subjects in 12-weeks after protocol approval of an ethical committee. The subjects consumed whole grain foods high in lignans (30 g/d of breakfast cereals or biscuits, etc., 80 g/d of whole grain pasta) or refined grain foods for 4 weeks, separated by a 2-weeks wash-out period. A modest hypocholesterolemic effect (p < 0.05) of the whole grain diet was observed and the intake of whole grain products rich in lignans was also associated with an increase in urinary enterodiol excretion (p < 0.05).
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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