No effect of dietary nitrate supplementation on endurance training in hypoxia
Puype J, Ramaekers M, Van Thienen R, Deldicque L, Hespel P
Scandinavian journal of medicine & science in sports · 25 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Fonds Wetenschappelijk Onderzoek
- Government
- Fonds Wetenschappelijk Onderzoek - Vlaanderen
- Grants
- Fonds Wetenschappelijk Onderzoek (G.0706.09N)
Based on 2 listed funder(s).
Publication
- Published
- 2014-03-20 · Scand J Med Sci Sports · vol. 25 · issue 2 · pp. 234–241
- Publisher
- Wiley
- Cited
- 40 citations · more than 93% of similar papers · 3.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 45 works
- Access
- Open access (repository copy) · OTHER-OA
- Research areas
- High Altitude and Hypoxia · Muscle metabolism and nutrition · Metabolomics and Mass Spectrometry Studies
- Keywords
- Hypoxia (environmental), Endurance training, Dietary Nitrate, Medicine, Nitrate, Physical therapy, Internal medicine, Biology, Chemistry, Oxygen
- MeSH
- humans, beta vulgaris, nitrates, muscle proteins, exercise test, blotting, western, reverse transcriptase polymerase chain reaction, altitude, adaptation, physiological, oxygen consumption, physical endurance, bicycling, dietary supplements, adolescent, adult, male, quadriceps muscle, young adult, real-time polymerase chain reaction, healthy volunteers, fruit and vegetable juices, hypoxia
5 authors
From BE
- Joke PuypeMaterialise (Belgium); KU Leuven
- Monique RamaekersMaterialise (Belgium); KU Leuven
- Ruud Van ThienenMaterialise (Belgium); KU Leuven
- Louise DeldicqueMaterialise (Belgium); KU Leuven
- Peter Hespel · correspondingMaterialise (Belgium); KU Leuven
Abstract
We investigated whether dietary nitrate (NO(3)(-)) supplementation enhances the effect of training in hypoxia on endurance performance at sea level. Twenty-two healthy male volunteers performed high-intensity endurance training on a cycle ergometer (6 weeks, 5×30 min/week at 4-6 mmol/L blood lactate) in normobaric hypoxia (12.5% FiO(2)), while ingesting either beetroot juice [0.07 mmol NO(3)(-) /kg body weight (bw)/day; BR, n = 11] or a control drink (CON, n = 11). During the pretest and the posttest, the subjects performed a 30-min simulated time trial (TT) and an incremental VO(2max) test. Furthermore, a biopsy was taken from m. vastus lateralis before and after the TT. Power output during the training sessions in both groups increased by ∼6% from week 1 to week 6 (P < 0.05). Compared with the pretest, VO(2max) in the posttest was increased (P < 0.05) in CON (5%) and BR (9%). Power output corresponding with the 4 mmol/L blood lactate threshold, as well as mean power output during TT increased by ∼16% in both groups (P < 0.05). Muscle phospho-AMP-activated protein kinase, hypoxia inducible factor-1α mRNA content, and glycogen breakdown during the TT were similar between the groups in both the pretest and the posttest. In conclusion, low-dose dietary NO(3)(-) supplementation does not enhance the effects of intermittent hypoxic training on endurance exercise performance at sea level.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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