Consumption of whole grains and legumes modulates the genetic effect of the APOA5 -1131C variant on changes in triglyceride and apolipoprotein A-V concentrations in patients with impaired fasting glucose or newly diagnosed type 2 diabetes
Kang R, Kim M, Chae JS, Lee SH, Lee JH
Trials · 25 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Government
- National Research Foundation
- Government
- National Research Foundation of Korea
- Grants
- National Research Foundation of Korea (2012M3A9C4048762)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2014-04-01 · Trials · vol. 15 · issue 1 · p. 100
- Publisher
- Springer Science+Business Media
- Cited
- 37 citations · more than 87% of similar papers · 2.2× the field average
- References
- 38 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Diabetes, Cardiovascular Risks, and Lipoproteins · Food composition and properties · Nutritional Studies and Diet
- Keywords
- Triglyceride, Hypertriglyceridemia, Internal medicine, Endocrinology, Medicine, Apolipoprotein B, Carbohydrate, Genotype, Type 2 diabetes, Legume, Diabetes mellitus, Biology, Cholesterol, Biochemistry, Gene, Agronomy
- MeSH
- humans, fabaceae, diabetes mellitus, type 2, insulin, dietary carbohydrates, blood glucose, triglycerides, apolipoproteins a, treatment outcome, fasting, genotype, phenotype, polymorphism, genetic, time factors, middle aged, female, male, republic of korea, biomarkers, oryza, edible grain, apolipoprotein a-v
5 authors
From KR
- Ryungwoo KangYonsei University
- Minjoo KimYonsei University
- Jey Sook ChaeYonsei University
- Sanghyun LeeNational Health Insurance Service Ilsan Hospital
- Jong Ho Lee · correspondingYonsei University
Abstract
Background
The apolipoprotein A5 gene (APOA5) -1131 T > C polymorphism is associated with mild hypertriglyceridemia in type 2 diabetic subjects, and interacts with dietary fat in the determination of triglyceride concentrations. We examined whether a substitution of whole grains and legumes for refined rice in a high carbohydrate diet (about 65% of energy derived from carbohydrate) may modify the effect of this variant on changes in apolipoprotein A-V (apoA-V) and triglyceride concentrations.
Methods
We genotyped the APOA5 -1131 T > C in individuals with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes, who were randomly assigned to either a group ingesting whole grain and legume meals daily or a control group for 12 weeks.
Results
After dietary intervention, we observed significant interactions between the APOA5 -1131 T > C polymorphism and carbohydrate sources (whole grains and legumes versus refined rice) in the determination of mean percent changes in triglyceride and apoA-V (P interactions <0.001 and =0.038, respectively). In the refined rice group (n = 93), the carriers of the risk C allele (n = 50) showed a greater increase in the mean percent changes of triglyceride and apoA-V than noncarriers after adjusting for HOMA-IR (P = 0.004 and 0.021, respectively). The whole grain and legume group (n = 92), however, showed a decrease in fasting glucose, HOMA-IR, and triglyceride, and an increase in apoA-V, irrespective of genotype.
Conclusions
The data showed that the magnitude of the genetic effect of the APOA5 -1131C variant on triglyceride and apoA-V levels was modulated when substituting consumption of whole grains and legumes for refined rice as a carbohydrate source in IFG or diabetic subjects.
Trial registration
ClinicalTrials.gov: NCT01784952.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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