Self-reported whole-grain intake and plasma alkylresorcinol concentrations in combination in relation to the incidence of colorectal cancer
Knudsen MD, Kyrø C, Olsen A, Dragsted LO, Skeie G, Lund E, Aman P, Nilsson LM, Bueno-de-Mesquita HB, Tjønneland A, Landberg R
American journal of epidemiology · 25 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- University or hospital
- Universitetet i Tromsø
- Nonprofit
- World Cancer Research Fund International
- University or hospital
- Imperial College London
- University or hospital
- Karolinska Institutet
- University or hospital
- Umeå Universitet
- Nonprofit
- World Cancer Research Fund
- University or hospital
- School of Public Health, Imperial College London
Based on 7 listed funder(s).
Publication
- Published
- 2014-04-03 · Am J Epidemiol · vol. 179 · issue 10 · pp. 1188–1196
- Publisher
- Oxford University Press
- Cited
- 44 citations · more than 97% of similar papers · 7.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 49 works
- Access
- Paywalled
- Research areas
- Nutritional Studies and Diet · Liver Disease Diagnosis and Treatment · Diet and metabolism studies
- Keywords
- Colorectal cancer, Incidence (geometry), Medicine, Whole grains, Internal medicine, Oncology, Cancer, Gastroenterology, Endocrinology, Physiology, Food science, Chemistry, Mathematics
- MeSH
- humans, colorectal neoplasms, resorcinols, diet, health behavior, life style, adult, middle aged, educational status, female, male, biomarkers, surveys and questionnaires, edible grain
11 authors
From DK, BE, NO, PK, SE, NL
- Markus Dines KnudsenDanish Cancer Society
- Cecilie Kyrø · correspondingDanish Cancer Society
- Anja OlsenDanish Cancer Society
- Lars Ove DragstedUniversity of Copenhagen; Nutrition Sciences (Belgium); Danish Cancer Society
- Guri SkeieCentre for Arctic Gas Hydrate, Environment and Climate; Danish Cancer Society; UiT The Arctic University of Norway
- Eiliv LundCentre for Arctic Gas Hydrate, Environment and Climate; Danish Cancer Society; UiT The Arctic University of Norway
Abstract
Self-reported food frequency questionnaires (FFQs) have occasionally been used to investigate the association between whole-grain intake and the incidence of colorectal cancer, but the results from those studies have been inconsistent. We investigated this association using intakes of whole grains and whole-grain products measured via FFQs and plasma alkylresorcinol concentrations, a biomarker of whole-grain wheat and rye intake, both separately and in combination (Howe's score with ranks). We conducted a nested case-control study in a cohort from a research project on Nordic health and whole-grain consumption (HELGA, 1992-1998). Incidence rate ratios and 95% confidence intervals were calculated using conditional logistic regression. Plasma alkylresorcinol concentrations alone and Howe's score with ranks were inversely associated with the incidence of distal colon cancer when the highest quartile was compared with the lowest (for alkylresorcinol concentrations, incidence rate ratio = 0.34, 95% confidence interval: 0.13, 0.92; for Howe's score with ranks, incidence rate ratio = 0.35, 95% confidence interval: 0.15, 0.86). No association was observed between whole-grain intake and any colorectal cancer (colon, proximal, distal or rectum cancer) when using an FFQ as the measure/exposure variable for whole-grain intake. The results suggest that assessing whole-grain intake using a combination of FFQs and biomarkers slightly increases the precision in estimating the risk of colon or rectal cancer by reducing the impact of misclassification, thereby increasing the statistical power of the study.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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