Does increased water intake prevent disease progression in autosomal dominant polycystic kidney disease?
Higashihara E, Nutahara K, Tanbo M, Hara H, Miyazaki I, Kobayashi K, Nitatori T
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 42 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2014-04-15 · Nephrol Dial Transplant · vol. 29 · issue 9 · pp. 1710–1719
- Publisher
- Oxford University Press
- Cited
- 63 citations · more than 96% of similar papers · 5.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 45 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Genetic and Kidney Cyst Diseases · Renal Diseases and Glomerulopathies · Ion Transport and Channel Regulation
- Keywords
- Medicine, Autosomal dominant polycystic kidney disease, Kidney disease, Disease, Polycystic kidney disease, Internal medicine, Endocrinology, Physiology
- MeSH
- kidney, humans, polycystic kidney, autosomal dominant, disease progression, glycopeptides, glomerular filtration rate, organ size, blood pressure, drinking, adult, middle aged, female, male, young adult
7 authors
From JP
- Eiji Higashihara · correspondingKyorin University
- Kikuo NutaharaKyorin University
- Mitsuhiro TanboKyorin University
- Hidehiko HaraKyorin University
- Isao MiyazakiKyorin University
- Kuninori KobayashiKyorin University
Abstract
Background
The clinical effects of increased water intake on autosomal dominant polycystic kidney disease (ADPKD) progression are unknown.
Methods
ADPKD patients with creatinine clearance ≧ 50 mL/min/1.73 m(2) were divided into high (H-, n = 18) and free (F-, n = 16) water-intake groups, mainly according to their preference. Prior to the study, 30 patients underwent annual evaluation of total kidney volume (TKV) and 24-h urine for an average of 33 months. During the 1-year study period, TKV and 24-h urine were analyzed at the beginning and end of the study and every 4 months, respectively.
Results
During the pre-study period, urine volume (UV) in the H-group was higher (P = 0.034), but TKV and kidney function and their slopes were not significantly different between the two groups. After the study commenced, UV further increased (P < 0.001) in the H-group but not in the F-group. During the study period, TKV and kidney function slopes were not significantly different between the two groups (primary endpoint). Plasma copeptin was lower (P = 0.024) in the H-group than in the F-group. TKV and kidney function slopes became worse (P = 0.047 and 0.011, respectively) after high water intake (H-group) but not in the F-group. High UV was associated with increased urine sodium, and urine sodium positively correlated with the % TKV slope (P = 0.014).
Conclusions
Although the main endpoint was not significant, high water intake enhanced disease progression in the H-group when compared with the pre-study period. These findings necessitate a long-term randomized study before drawing a final conclusion.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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