Olive oil consumption and risk of CHD and/or stroke: a meta-analysis of case-control, cohort and intervention studies
Martínez-González MA, Dominguez LJ, Delgado-Rodríguez M
The British journal of nutrition · 82 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Plan Nacional sobre Drogas
- Government
- Instituto de Salud Carlos III
- Government
- European Regional Development Fund
- Grants
- Instituto de Salud Carlos III (2010/087); Instituto de Salud Carlos III (PI1002658); Instituto de Salud Carlos III (RTIC G03/140); Instituto de Salud Carlos III (06/0045); Instituto de Salud Carlos III (RD06/0045); European Regional Development Fund (06/0045); Plan Nacional sobre Drogas (RD 06/0045); Instituto de Salud Carlos III (PI07/0240); Plan Nacional sobre Drogas (PI1002658); Plan Nacional sobre Drogas (G03/140); European Regional Development Fund (CB12/03/30017); Instituto de Salud Carlos III (RTIC G03/140 and RTIC RD 06/0045); Instituto de Salud Carlos III (RTIC RD06/0045); European Regional Development Fund (PI07/0240); Instituto de Salud Carlos III (G03/140); European Regional Development Fund (RTIC G03/140); European Regional Development Fund ((RD 06/0045); European Regional Development Fund (CB12/03); European Regional Development Fund (G03/140); Plan Nacional sobre Drogas (2010/087)
Based on 3 listed funder(s).
Publication
- Published
- 2014-04-28 · Br J Nutr · vol. 112 · issue 2 · pp. 248–259
- Publisher
- Cambridge University Press
- Cited
- 108 citations · more than 75% of similar papers · 1.4× the field average
- References
- 39 works
- Access
- Free to read
- Research areas
- Nutritional Studies and Diet · Consumer Attitudes and Food Labeling · Sodium Intake and Health
- Keywords
- Medicine, Stroke (engine), Mediterranean diet, Funnel plot, Relative risk, Meta-analysis, Cohort study, Cohort, Publication bias, Internal medicine, Lower risk, Prospective cohort study, Randomized controlled trial, Confidence interval
- MeSH
- humans, olea, fruit, coronary disease, plant oils, incidence, risk factors, case-control studies, cohort studies, reproducibility of results, evidence-based medicine, diet, mediterranean, randomized controlled trials as topic, stroke, olive oil
3 authors
From ES, IT
- Miguel Ángel Martínez‐GonzálezUniversidad Pública de Navarra (UPNA); Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red; Universidad de Navarra
- Ligia Juliana Dominguez · correspondingUniversity of Palermo
- Miguel Delgado‐RodríguezUniversidad de Jaén; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Abstract
Increasing evidence suggests that the Mediterranean diet can reduce the risk of CVD. Olive oil is the hallmark of this dietary pattern. We conducted a meta-analysis of case-control, prospective cohort studies and a randomised controlled trial investigating the specific association between olive oil consumption and the risk of CHD (101,460 participants) or stroke (38,673 participants). The results of all observational studies were adjusted for total energy intake. The random-effects model assessing CHD as an outcome showed a relative risk (RR) of 0.73 (95% CI 0.44, 1.21) in case-control studies and 0.96 (95% CI 0.78, 1.18) in cohort studies for a 25 g increase in olive oil consumption. In cohort studies, the random-effects model assessing stroke showed a RR of 0.74 (95% CI 0.60, 0.92). The random-effects model combining all cardiovascular events (CHD and stroke) showed a RR of 0.82 (95% CI 0.70, 0.96). Evidence of heterogeneity was apparent for CHD, but not for stroke. Both the Egger test (P= 0.06) and the funnel plot suggested small-study effects. Available studies support an inverse association of olive oil consumption with stroke (and with stroke and CHD combined), but no significant association with CHD. This finding is in agreement with the recent successful results of the PREDIMED randomised controlled trial.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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