Extravirgin olive oil consumption reduces risk of atrial fibrillation: the PREDIMED (Prevención con Dieta Mediterránea) trial
Martínez-González MÁ, Toledo E, Arós F, Fiol M, Corella D, Salas-Salvadó J, Ros E, Covas MI, Fernández-Crehuet J, Lapetra J, Muñoz MA, Fitó M, Serra-Majem L, Pintó X, Lamuela-Raventós RM, Sorlí JV, Babio N, Buil-Cosiales P, Ruiz-Gutierrez V, Estruch R, Alonso A, PREDIMED Investigators
Circulation · 165 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2014-05-01 · Circulation · vol. 130 · issue 1 · pp. 18–26
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 218 citations · more than 100% of similar papers · 20.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 43 works
- Access
- Free to read
- Research areas
- Nutritional Studies and Diet · Nuts composition and effects · Bariatric Surgery and Outcomes
- Keywords
- Medicine, Atrial fibrillation, Olive oil, Consumption (sociology), Cardiology, Internal medicine, Food science
- MeSH
- humans, nuts, atrial fibrillation, inflammation, dietary fats, plant oils, treatment outcome, diet, fat-restricted, incidence, proportional hazards models, risk, risk factors, follow-up studies, oxidative stress, diet, mediterranean, aged, middle aged, spain, female, male, stroke, olive oil
22 authors
From ES, US
- Miguel Ángel Martínez‐GonzálezInstituto de Salud Carlos III; Centro de Investigación Biomédica en Red; Universidad de Navarra
- Estefanía ToledoInstituto de Salud Carlos III; Centro de Investigación Biomédica en Red; Universidad de Navarra
- Fernando ArósInstituto de Salud Carlos III; Hospital Universitario Araba; Centro de Investigación Biomédica en Red
- Miquel FiolInstituto de Salud Carlos III; Centro de Investigación Biomédica en Red; Health Research Institute of the Balearic Islands
- Dolores CorellaUniversitat de València; Instituto de Salud Carlos III; Centro de Investigación Biomédica en Red
- Jordi Salas‐SalvadóInstituto de Salud Carlos III; Institut de Recerca Biomèdica Catalunya Sud; Centro de Investigación Biomédica en Red; Hospital Universitari Sant Joan de Reus; Universitat Rovira i Virgili
Abstract
Background
The PREDIMED (Prevención con Dieta Mediterránea) randomized primary prevention trial showed that a Mediterranean diet enriched with either extravirgin olive oil or mixed nuts reduces the incidence of stroke, myocardial infarction, and cardiovascular mortality. We assessed the effect of these diets on the incidence of atrial fibrillation in the PREDIMED trial.
Methods and results
Participants were randomly assigned to 1 of 3 diets: Mediterranean diet supplemented with extravirgin olive oil, Mediterranean diet supplemented with mixed nuts, or advice to follow a low-fat diet (control group). Incident atrial fibrillation was adjudicated during follow-up by an events committee blinded to dietary group allocation. Among 6705 participants without prevalent atrial fibrillation at randomization, we observed 72 new cases of atrial fibrillation in the Mediterranean diet with extravirgin olive oil group, 82 in the Mediterranean diet with mixed nuts group, and 92 in the control group after median follow-up of 4.7 years. The Mediterranean diet with extravirgin olive oil significantly reduced the risk of atrial fibrillation (hazard ratio, 0.62; 95% confidence interval, 0.45-0.85 compared with the control group). No effect was found for the Mediterranean diet with nuts (hazard ratio, 0.89; 95% confidence interval, 0.65-1.20).
Conclusions
In the absence of proven interventions for the primary prevention of atrial fibrillation, this post hoc analysis of the PREDIMED trial suggests that extravirgin olive oil in the context of a Mediterranean dietary pattern may reduce the risk of atrial fibrillation.
Clinical trial registration url
http://www.controlled-trials.com. Unique identifier: ISRCTN35739639.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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