Replacing with whole grains and legumes reduces Lp-PLA2 activities in plasma and PBMCs in patients with prediabetes or T2D
Kim M, Jeung SR, Jeong TS, Lee SH, Lee JH
Journal of lipid research · 15 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2014-06-06 · J Lipid Res · vol. 55 · issue 8 · pp. 1762–1771
- Publisher
- Elsevier BV
- Cited
- 21 citations · more than 64% of similar papers · 0.4× the field average
- References
- 45 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Food composition and properties · Fatty Acid Research and Health · Lipoproteins and Cardiovascular Health
- Keywords
- Internal medicine, Endocrinology, Peripheral blood mononuclear cell, Insulin resistance, Lipoprotein, Chemistry, Glycated hemoglobin, Triglyceride, Glycemic, Insulin, Malondialdehyde, Type 2 diabetes, Medicine, Diabetes mellitus, Oxidative stress, Biochemistry, Cholesterol
- MeSH
- leukocytes, mononuclear, humans, fabaceae, diabetes mellitus, type 2, prediabetic state, malondialdehyde, 1-alkyl-2-acetylglycerophosphocholine esterase, lipoproteins, ldl, middle aged, female, male, whole grains
5 authors
From KR
- Minjoo KimYonsei University
- Se Ri JeungYonsei University
- Tae‐Sook JeongKorea Research Institute of Bioscience and Biotechnology
- Sang‐Hyun LeeNational Health Insurance Service
- Jong Ho Lee · correspondingYonsei University; National Health Insurance Service
Abstract
To determine dietary effects on circulating lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and enzyme activity in peripheral blood mononuclear cells (PBMCs), 99 patients with impaired fasting glucose, impaired glucose tolerance, or newly-diagnosed T2D were randomly assigned to either a control group (usual diet with refined rice) or the whole grain and legume group. Substitution of whole grains and legumes for refined rice was associated with the replacement of 7% of energy from carbohydrates with energy from protein (about 4%) and fat. After 12 weeks, the whole grain and legume group showed a significant decrease in fasting glucose, insulin, homeostasis model assessment-insulin resistance, hemoglobin A1c, malondialdehyde, plasma Lp-PLA2 activity, and oxidized LDL (ox-LDL), and an increase in LDL particle size. The changes (Δs) in these variables in the whole grain and legume group were significantly different from those in controls after adjustment for the baseline levels. When all subjects were considered, Δ plasma Lp-PLA2 positively correlated with Δ glucose, Δ PBMC Lp-PLA2, Δ ox-LDL, and Δ urinary 8-epi-prostaglandin F2α after being adjusted for confounding factors. The Δ PBMC Lp-PLA2 correlated positively with Δ glucose and Δ ox-LDL, and negatively with Δ LDL particle size and baseline PBMC Lp-PLA2 The substitution of whole grains and legumes for refined rice resulted in a reduction in Lp-PLA2 activities in plasma and PBMCs partly through improved glycemic control, increased consumption of protein relative to carbohydrate, and reduced lipid peroxides.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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