The effect of magnesium supplements on early post-transplantation glucose metabolism: a randomized controlled trial
Van Laecke S, Nagler EV, Taes Y, Van Biesen W, Peeters P, Vanholder R
Transplant international : official journal of the European Society for Organ Transplantation · 41 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2014-02-24 · Transpl Int · vol. 27 · issue 9 · pp. 895–902
- Publisher
- Springer Science+Business Media
- Cited
- 45 citations · more than 92% of similar papers · 3.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 51 works
- Access
- Paywalled
- Research areas
- Magnesium in Health and Disease · Hemoglobinopathies and Related Disorders
- Keywords
- Medicine, Randomized controlled trial, Magnesium, Transplantation, Internal medicine, Carbohydrate metabolism
- MeSH
- humans, kidney failure, chronic, diabetes mellitus, type 2, prediabetic state, insulin resistance, magnesium deficiency, graft vs host disease, postoperative complications, diarrhea, magnesium, magnesium oxide, tacrolimus, receptor, insulin, blood glucose, glucose tolerance test, kidney transplantation, severity of illness index, area under curve, adult, aged, middle aged, female, male, calcineurin inhibitors
6 authors
From BE
- Steven Van Laecke · correspondingGhent University Hospital
- Evi Vanessa NaglerGhent University Hospital
- Youri TaesGhent University Hospital
- Wim Van BiesenGhent University Hospital
- Patrick C. PeetersGhent University Hospital
- Raymond Camille VanholderGhent University Hospital
Abstract
Post-transplantation hypomagnesemia is common and predicts diabetes. Magnesium improves glycemic control in diabetics and insulin sensitivity in insulin resistant subjects. We aimed to assess the effectiveness of oral magnesium for improving glycemic control and insulin sensitivity at 3 months post-transplantation. We conducted a single-center, open-label, randomized parallel group study. We included adults with serum magnesium <1.7 mg/dl within 2 weeks after kidney transplantation. We randomized participants to 450 mg magnesium oxide up to three times daily or no treatment. The primary endpoint was the mean difference in fasting glycemia. Secondary endpoints were the mean difference in area under the curve (AUC) of glucose during an oral glucose tolerance test and insulin resistance measured by Homeostasis Model of Assessment-Insulin Resistance (HOMA-IR). Analyses were on intention-to-treat basis. In patients randomized to magnesium oxide (N = 27) versus no treatment (N = 27), fasting glycemia on average was 11.5 mg/dl lower (95% CI 1.7 to 21.3; P = 0.02). There was no difference between the two groups neither for 2 h AUC, where the mean value was 1164 mg/dl/min (95% CI -1884 to 4284; P = 0.45) lower in the treatment group nor for HOMA-IR. Magnesium supplements modestly improved fasting glycemia without effect on insulin resistance. Higher baseline glycemia among patients in the control group may have driven the positive outcome (ClinicalTrials.gov number: NCT01889576).
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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