Dietary magnesium intake and risk of cancer: a meta-analysis of epidemiologic studies
Ko HJ, Youn CH, Kim HM, Cho YJ, Lee GH, Lee WK
Nutrition and cancer · 29 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2014-06-09 · Nutr Cancer · vol. 66 · issue 6 · pp. 915–923
- Publisher
- Routledge
- Cited
- 50 citations · more than 40% of similar papers · 0.2× the field average
- References
- 50 works
- Access
- Paywalled
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments
- Keywords
- Meta-analysis, Medicine, Environmental health, Magnesium, Cancer, Internal medicine, Chemistry
- MeSH
- humans, colorectal neoplasms, magnesium, diet, risk factors, observational studies as topic
6 authors
From KR
- Hae‐Jin KoKyungpook National University
- Chang Ho Youn · correspondingKyungpook National University
- Hyo Min KimKyungpook National University Medical Center
- Yoon Jeong ChoDaegu Catholic University
- Geon Ho LeeDaegu Catholic University
- Won Kee LeeKyungpook National University
Abstract
The aim of this study was to investigate the association between dietary magnesium and the risk of overall cancer using a meta-analysis. We searched PubMed, SCOPUS, and the Cochrane Review through November 2012. All the articles searched were independently reviewed by 3 authors based on predetermined selection criterion. A total of 13 epidemiologic studies, 6 case-control studies, and 7 prospective cohort studies involving 1,236,004 participants were included in the final analysis. When all studies were pooled, the relative risk (RR) of overall cancer for the highest level of dietary magnesium intake was 0.801 [95% confidence interval (CI): 0.664-0.966) compared with the lowest level of dietary magnesium intake. In subgroup meta-analyses by study design, there was a significant inverse association between dietary magnesium and the risk of cancer in case-control studies (RR = 0.663, 95% CI: 0.475-0.925), whereas there was no significant association in prospective cohort studies (RR = 0.888, 95% CI: 0.745-1.060). Furthermore, there was a significant preventive effect of dietary magnesium for colorectal cancer (RR = 0.775, 95% CI: 0.655-0.919), but not for other cancer. Our meta-analysis showed that higher dietary magnesium intake seems to have a protective effect for cancer, especially colorectal cancer and in females.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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