Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China
Egner PA, Chen JG, Zarth AT, Ng DK, Wang JB, Kensler KH, Jacobson LP, Muñoz A, Johnson JL, Groopman JD, Fahey JW, Talalay P, Zhu J, Chen TY, Qian GS, Carmella SG, Hecht SS, Kensler TW
Cancer prevention research (Philadelphia, Pa.) · 144 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Institute of Environmental Health Sciences
- Government
- NIEHS NIH HHS
- Grants
- National Institute of Environmental Health Sciences (P30 ES 003819); National Institute of Environmental Health Sciences (P01 ES006052)
Based on 2 listed funder(s).
Publication
- Published
- 2014-06-10 · Cancer Prev Res (Phila) · vol. 7 · issue 8 · pp. 813–823
- Publisher
- American Association for Cancer Research
- Cited
- 192 citations · more than 98% of similar papers · 7.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 49 works
- Access
- Open access (repository copy)
- Research areas
- Genomics, phytochemicals, and oxidative stress · Air Quality and Health Impacts
- Keywords
- Sulforaphane, Mercapturic acid, Glucoraphanin, Excretion, Chemistry, Cruciferous vegetables, Urine, Glutathione, Food science, Glucosinolate, Bioavailability, Brassica, Pharmacology, Medicine, Biochemistry, Botany, Biology, Enzyme, Internal medicine
- MeSH
- humans, brassica, oximes, imidoesters, isothiocyanates, sulfoxides, glutathione transferase, glucosinolates, air pollutants, chromatography, liquid, air pollution, biological availability, genotype, polymorphism, single nucleotide, time factors, beverages, adult, aged, middle aged, china, female, male, mass spectrometry, young adult, biomarkers
18 authors
From US, CN
- Patricia A. EgnerJohns Hopkins University
- Jianguo ChenQidong Liver Cancer Prevention Research
- Adam T. ZarthUniversity of Minnesota; University of Minnesota Medical Center
- Derek K. NgJohns Hopkins University
- Jin-Bing WangQidong Liver Cancer Prevention Research
- Kevin H. KenslerJohns Hopkins University
Abstract
Broccoli sprouts are a convenient and rich source of the glucosinolate, glucoraphanin, which can generate the chemopreventive agent, sulforaphane, an inducer of glutathione S-transferases (GST) and other cytoprotective enzymes. A broccoli sprout-derived beverage providing daily doses of 600 μmol glucoraphanin and 40 μmol sulforaphane was evaluated for magnitude and duration of pharmacodynamic action in a 12-week randomized clinical trial. Two hundred and ninety-one study participants were recruited from the rural He-He Township, Qidong, in the Yangtze River delta region of China, an area characterized by exposures to substantial levels of airborne pollutants. Exposure to air pollution has been associated with lung cancer and cardiopulmonary diseases. Urinary excretion of the mercapturic acids of the pollutants, benzene, acrolein, and crotonaldehyde, were measured before and during the intervention using liquid chromatography tandem mass spectrometry. Rapid and sustained, statistically significant (P ≤ 0.01) increases in the levels of excretion of the glutathione-derived conjugates of benzene (61%), acrolein (23%), but not crotonaldehyde, were found in those receiving broccoli sprout beverage compared with placebo. Excretion of the benzene-derived mercapturic acid was higher in participants who were GSTT1-positive than in the null genotype, irrespective of study arm assignment. Measures of sulforaphane metabolites in urine indicated that bioavailability did not decline over the 12-week daily dosing period. Thus, intervention with broccoli sprouts enhances the detoxication of some airborne pollutants and may provide a frugal means to attenuate their associated long-term health risks.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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