The Effects of Tocotrienols Added to Canola Oil on Microalbuminuria, Inflammation, and Nitrosative Stress in Patients with Type 2 Diabetes: A Randomized, Double-blind, Placebo-controlled Trial
Haghighat N, Vafa M, Eghtesadi S, Heidari I, Hosseini A, Rostami A
International journal of preventive medicine · 27 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2014-05-01 · Int J Prev Med · vol. 5 · issue 5 · pp. 617–23
- Publisher
- National Institutes of Health
- Cited
- 28 citations · more than 77% of similar papers · 1.2× the field average
- References
- 22 works
- Access
- Open access (repository copy) · CC-BY-NC-SA
- Research areas
- Coconut Research and Applications · Antioxidant Activity and Oxidative Stress · Fatty Acid Research and Health
- Keywords
- Microalbuminuria, Medicine, Placebo, Urine, Creatinine, Canola, Internal medicine, Proteinuria, Randomized controlled trial, Endocrinology, Gastroenterology, Renal function, Kidney, Food science, Chemistry, Pathology
6 authors
From IR
- Neda HaghighatTehran University of Medical Sciences
- Mohammadreza VafaIran University of Medical Sciences; Tehran University of Medical Sciences
- Shahryar EghtesadiTehran University of Medical Sciences
- Iraj HeidariIran University of Medical Sciences
- Agha Fatemeh HosseiniIran University of Medical Sciences
- Ali RostamiTehran University of Medical Sciences
Abstract
Background
Tocotrienols (T3) were neglected in the past; today, get attentions due to their antioxidant and none-antioxidant activity. The objective of this study was to evaluate the effects of the daily intake of 200 mg T3 added in canola oil over 8 weeks on microalbuminuria, inflammation, and nitrosative stress in type 2 diabetic patients.
Methods
This study was a double-blinded, placebo-controlled, randomized trial. A total of 50 patients with T2DM and FBS >126 mg/dl treated by non-insulin hypoglycemic drugs were randomly assigned to receive either 15 ml T3-enriched canola oil (200 mg/day T3) or pure canola oil for 8 weeks. Urine microalbumin, volume and creatinine levels, serum hs-CRP, and nitric oxide (NO) levels were measured before and after intervention.
Results
From 50 patients participated in this study, 44 completed the study. There were no significant differences in baseline characteristics, dietary intake, and physical activity between groups. Urine microalbumin and serum hs-CRP were declined significantly in T3-treated group. At the end of the study, patients who treated with T3 had lower urine microalbumin (11 (9, 25) vs. 22 (15, 39.75) nmol/dl, P = 0.003) and hs-CRP changes (-10.91 ± 15.5 vs. -9.88 ± 27.5 Pg/ml, P = 0.048) than control group. A non-significant decrease was also observed in serum NO level in T3-treated group with no changes in urine volume and creatinine levels.
Conclusions
These findings indicate that T3 leads to ameliorate proteinuria and can protect the kidney against inflammation (hs-CRP) and nitrosative stress (NO).
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-SA).
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