Dietary magnesium intake and risk of metabolic syndrome: a meta-analysis
Dibaba DT, Xun P, Fly AD, Yokota K, He K
Diabetic medicine : a journal of the British Diabetic Association · 55 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Institute of Environmental Health Sciences
- Government
- National Center for Advancing Translational Sciences
- Government
- NHLBI NIH HHS
- Government
- NIEHS NIH HHS
- Government
- NCATS NIH HHS
- Grants
- National Heart, Lung, and Blood Institute (R01 HL081572); National Institute of Environmental Health Sciences (R01ES021735); National Center for Advancing Translational Sciences (UL1TR-001108); National Institutes of Health (R01ES021735); National Institutes of Health (R01HL081572)
Based on 7 listed funder(s).
Publication
- Published
- 2014-06-26 · Diabet Med · vol. 31 · issue 11 · pp. 1301–1309
- Publisher
- Wiley
- Cited
- 89 citations · more than 92% of similar papers · 3.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 51 works
- Access
- Open access (repository copy)
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Magnesium Alloys: Properties and Applications
- Keywords
- Medicine, Metabolic syndrome, Odds ratio, Meta-analysis, Internal medicine, Placebo, Randomized controlled trial, Cohort study, Magnesium deficiency (plants), Relative risk, Magnesium, Confidence interval, Endocrinology, Obesity, Pathology
- MeSH
- humans, magnesium deficiency, magnesium, diet, prevalence, risk factors, cross-sectional studies, evidence-based medicine, metabolic syndrome
5 authors
From US, JP
- Daniel Tefera DibabaIndiana University Bloomington
- Pengcheng XunIndiana University Bloomington
- Alyce D. FlyIndiana University Bloomington
- Kaito YokotaJikei University School of Medicine
- Ka He · correspondingIndiana University Bloomington
Abstract
Aims
To estimate quantitatively the association between dietary magnesium intake and risk of metabolic syndrome by combining the relevant published articles using meta-analysis.
Methods
We reviewed the relevant literature in PubMed and EMBASE published up until August 2013 and obtained additional information through Google or a hand search of the references in relevant articles. A random-effects or fixed-effects model, as appropriate, was used to pool the effect sizes on metabolic syndrome comparing individuals with the highest dietary magnesium intake with those having the lowest intake. The dose-response relationship was assessed for every 100-mg/day increment in magnesium intake and risk of metabolic syndrome.
Result
Six cross-sectional studies, including a total of 24 473 individuals and 6311 cases of metabolic syndrome, were identified as eligible for the meta-analysis. A weighted inverse association was found between dietary magnesium intake and the risk of metabolic syndrome (odds ratio 0.69, 95% CI 0.59, 0.81) comparing the highest with the lowest group. For every 100-mg/day increment in magnesium intake, the overall risk of having metabolic syndrome was lowered by 17% (odds ratio 0.83, 95% CI 0. 77, 0.89).
Conclusion
Findings from the present meta-analysis suggest that dietary magnesium intake is inversely associated with the prevalence of metabolic syndrome. Further studies, in particular well-designed longitudinal cohort studies and randomized placebo-controlled clinical trials, are warranted to provide solid evidence and to establish causal inference.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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