Pistachio nut consumption modifies systemic hemodynamics, increases heart rate variability, and reduces ambulatory blood pressure in well-controlled type 2 diabetes: a randomized trial
Sauder KA, McCrea CE, Ulbrecht JS, Kris-Etherton PM, West SG
Journal of the American Heart Association · 40 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Industry funded
- Government
- National Institutes of Health
- Government
- National Institute on Aging
- Government
- National Center for Research Resources
- Government
- National Center for Advancing Translational Sciences
- Government
- NIA NIH HHS
- Government
- NCRR NIH HHS
- Government
- NCATS NIH HHS
- Authors
- At least one author declares a financial tie to industry
- Grants
- National Center for Advancing Translational Sciences (UL1-TR000127); National Center for Research Resources (UL1 RR033184); National Institute on Aging (F31 AG043224); National Institutes of Health (1ul1rr033184-01); National Institutes of Health (UL1-TR-000127)
Based on 7 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2014-07-01 · J Am Heart Assoc · vol. 3 · issue 4
- Publisher
- Wiley
- Cited
- 54 citations · more than 92% of similar papers · 3.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 41 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Nuts composition and effects · Nutritional Studies and Diet · Peanut Plant Research Studies
- Keywords
- Medicine, Blood pressure, Heart rate, Crossover study, Hemodynamics, Glycemic, Type 2 diabetes, Diabetes mellitus, Internal medicine, Ambulatory blood pressure, Ambulatory, Cardiology, Randomized controlled trial, Endocrinology, Placebo
- MeSH
- humans, pistacia, cardiovascular diseases, diabetes mellitus, type 2, hypoglycemic agents, blood pressure monitoring, ambulatory, cardiac output, cross-over studies, stress, psychological, risk reduction behavior, blood pressure, heart rate, vascular resistance, adult, aged, middle aged, female, male, hemodynamics
5 authors
From US
- Katherine Ann SauderPennsylvania State University
- Cindy E McCreaPennsylvania State University
- Jan S. UlbrechtPennsylvania State University
- Penny M. Kris‐EthertonPennsylvania State University
- Sheila G. WestPennsylvania State University
Abstract
Background
Managing cardiovascular risk factors is important for reducing vascular complications in type 2 diabetes, even in individuals who have achieved glycemic control. Nut consumption is associated with reduced cardiovascular risk; however, there is mixed evidence about the effect of nuts on blood pressure (BP), and limited research on the underlying hemodynamics. This study assessed the effect of pistachio consumption on BP, systemic hemodynamics, and heart rate variability in adults with well-controlled type 2 diabetes.
Methods and results
We enrolled 30 adults (40 to 74 years) with type 2 diabetes in a randomized, crossover, controlled feeding study. After a 2-week run-in period, participants consumed a low-fat control diet (27% fat) containing low-fat/high-carbohydrate snacks and a moderate-fat diet (33% fat) containing pistachios (20% of total energy) for 4 weeks each, separated by a 2-week washout. Following each diet period, we assessed BP, systemic hemodynamics, and heart rate variability at rest and during acute mental stress, and, in a subset of participants (n=21), 24-hour ambulatory BP. BP at rest and during stress did not differ between treatments. The pistachio diet significantly reduced total peripheral resistance (-3.7±2.9%, P=0.004), increased cardiac output (3.1±2.3%, P=0.002), and improved some measures of heart rate variability (all P<0.05). Systolic ambulatory BP was significantly reduced by 3.5±2.2 mm Hg (P=0.046) following the pistachio diet, with the greatest reduction observed during sleep (-5.7±2.6 mm Hg, P=0.052).
Conclusions
A moderate-fat diet containing pistachios modestly improves some cardiovascular risk factors in adults with well-controlled type 2 diabetes.
Clinical trial registration url
www.clinicaltrials.gov. Unique identifier: NCT00956735.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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