Faecal microbial metabolism of olive oil phenolic compounds: in vitro and in vivo approaches
Mosele JI, Martín-Peláez S, Macià A, Farràs M, Valls RM, Catalán Ú, Motilva MJ, Motilva MJ
Molecular nutrition & food research · 72 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Mechanisms only
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- University or hospital
- Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
- University or hospital
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
- Government
- Spanish Ministry of Economy and Competitiveness (MINECO)
- Government
- Spanish Ministry of Health
- Government
- Generalitat de Catalunya through the J. Mosele grant
- Government
- CIBEROBN
- Government
- Health Institute of Carlos III
- Unclassified
- FPI contract
- Government
- CIBERDEM
- Grants
- Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición (CB06/03)
Based on 9 listed funder(s).
Publication
- Published
- 2014-07-02 · Mol Nutr Food Res · vol. 58 · issue 9 · pp. 1809–1819
- Publisher
- Wiley
- Cited
- 99 citations · more than 89% of similar papers · 2.7× the field average
- References
- 45 works
- Access
- Paywalled
- Research areas
- Edible Oils Quality and Analysis · Phytochemicals and Antioxidant Activities · Fermentation and Sensory Analysis
- Keywords
- Hydroxytyrosol, Tyrosol, Oleuropein, Phenols, Chemistry, Food science, Syringic acid, Verbascoside, Phenol, Metabolism, Polyphenol, Biochemistry, Olive oil, Organic chemistry, Antioxidant, Gallic acid
- MeSH
- colon, feces, humans, phenylethyl alcohol, acetates, iridoids, phenols, catechols, plant oils, fermentation, kinetics, nontherapeutic human experimentation, iridoid glucosides, microbiota, in vitro techniques, olive oil
7 authors
From ES
- Juana I. MoseleUniversitat de Lleida; Agrotecnio - Centre for Food and Agriculture Research
- Sandra Martín‐PeláezBarcelona Biomedical Research Park; Hospital del Mar Research Institute
- Alba MaciàUniversitat de Lleida; Agrotecnio - Centre for Food and Agriculture Research
- Marta FarràsUniversitat Autònoma de Barcelona; Barcelona Biomedical Research Park; Hospital del Mar Research Institute
- Rosa M. VallsInstitut de Recerca Biomèdica Catalunya Sud; Centro de Investigación Biomédica en Red; Hospital Universitari Sant Joan de Reus; Universitat Rovira i Virgili
- Úrsula CatalánInstitut de Recerca Biomèdica Catalunya Sud; Centro de Investigación Biomédica en Red; Hospital Universitari Sant Joan de Reus; Universitat Rovira i Virgili
Abstract
Scope
In the present study, the individual colonic metabolism of the main components of the virgin olive oil phenolic fraction was evaluated by an in vitro model using human faecal microbiota. To assess differences in metabolism related to the molecular structure, four phenolic standards were selected, tyrosol, hydroxytyrosol, hydroxytyrosol acetate and oleuropein. After studying the in vitro colonic metabolism pathways of the individual phenols, the presence of their colonic metabolites was investigated in human faecal samples obtained before and after the sustained intake (3 weeks) of a daily dose of 25 mL of a phenol-enriched olive oil.
Methods and results
The in vitro colon fermentation of the four individual phenolic compounds revealed (i) an increase in phenolic acids, (ii) the stability of hydroxytyrosol and tyrosol and (iii) the high degradation of hydroxytyrosol acetate and oleuropein. Additionally, a moderate intake of a phenol-rich olive oil raised the concentration in human faeces of free hydroxytyrosol and phenylacetic and phenylpropionic acids.
Conclusion
The products of colonic catabolism of olive oil phenolic compounds could be good candidates for novel preventive strategies and open a promising line of research into the preventive action of olive oil phenols in colon and other bowel diseases.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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