Funded in part by Egg Nutrition Center
Egg intake during carbohydrate restriction alters peripheral blood mononuclear cell inflammation and cholesterol homeostasis in metabolic syndrome
Andersen CJ, Lee JY, Blesso CN, Carr TP, Fernandez ML
Nutrients · 20 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Government
- U.S. Department of Agriculture
- Industry group
- Egg Nutrition Center
- Government
- National Institute of Food and Agriculture
- Authors
- At least one author declares a financial tie to industry
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2014-07-18 · Nutrients · vol. 6 · issue 7 · pp. 2650–2667
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 30 citations · more than 85% of similar papers · 1.8× the field average
- References
- 64 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Diet, Metabolism, and Disease · Diet and metabolism studies · Liver Disease Diagnosis and Treatment
- Keywords
- Peripheral blood mononuclear cell, Homeostasis, Inflammation, Glucose homeostasis, Endocrinology, Metabolic syndrome, Internal medicine, Peripheral, Cholesterol, Carbohydrate, Biology, Medicine, Physiology, Obesity, Insulin resistance, Biochemistry
- MeSH
- leukocytes, mononuclear, humans, inflammation, cholesterol, hydroxymethylglutaryl coa reductases, dietary carbohydrates, lipopolysaccharides, dietary fats, tumor necrosis factor-alpha, dietary proteins, nf-kappa b, rna, messenger, single-blind method, homeostasis, eggs, adult, aged, middle aged, female, male, diet, carbohydrate-restricted, toll-like receptor 4, interleukin-1beta, atp binding cassette transporter 1, metabolic syndrome
5 authors
From US
- Catherine J. AndersenUniversity of Connecticut
- Ji‐Young LeeUniversity of Connecticut
- Christopher N. BlessoUniversity of Connecticut
- Timothy P. CarrUniversity of Nebraska–Lincoln
- María Luz FernándezUniversity of Connecticut
Abstract
Egg yolk contains bioactive components that improve plasma inflammatory markers and HDL profiles in metabolic syndrome (MetS) under carbohydrate restriction. We further sought to determine whether egg yolk intake affects peripheral blood mononuclear cell (PBMC) inflammation and cholesterol homeostasis in MetS, as HDL and its associated lipid transporter ATP-binding cassette transporter A1 (ABCA1) reduce the inflammatory potential of leukocytes through modulation of cellular cholesterol content and distribution. Thirty-seven men and women classified with MetS consumed a moderate carbohydrate-restricted diet (25%-30% of energy) for 12 weeks, in addition to consuming either three whole eggs per day (EGG) or the equivalent amount of yolk-free egg substitute (SUB). Interestingly, lipopolysaccharide-induced PBMC IL-1β and TNFα secretion increased from baseline to week 12 in the SUB group only, despite increases in PBMC toll-like receptor 4 (TLR4) mRNA expression in the EGG group. Compared to baseline, ABCA1 and 3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase mRNA expression increased by week 12 in the EGG group only, whereas changes in PBMC total cholesterol positively correlated with changes in lipid raft content. Together, these findings suggest that intake of whole eggs during carbohydrate restriction alters PBMC inflammation and cholesterol homeostasis in MetS.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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