Immunomodulatory effect of a wild blueberry anthocyanin-rich extract in human Caco-2 intestinal cells
Taverniti V, Fracassetti D, Del Bo' C, Lanti C, Minuzzo M, Klimis-Zacas D, Riso P, Guglielmetti S
Journal of agricultural and food chemistry · 56 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Fondazione Cariplo
- Grants
- Fondazione Cariplo (2010-2303)
Based on 1 listed funder(s).
Publication
- Published
- 2014-07-30 · J Agric Food Chem · vol. 62 · issue 33 · pp. 8346–8351
- Publisher
- American Chemical Society
- Cited
- 88 citations · more than 95% of similar papers · 3.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 48 works
- Access
- Open access (repository copy) · OTHER-OA
- Research areas
- Phytochemicals and Antioxidant Activities · Polysaccharides and Plant Cell Walls · Natural Antidiabetic Agents Studies
- Keywords
- Caco-2, Anthocyanin, Food science, Biology, Chemistry, Traditional medicine, Biochemistry, In vitro, Medicine
- MeSH
- intestines, caco-2 cells, humans, inflammation, anthocyanins, nf-kappa b, anti-inflammatory agents, plant extracts, models, biological, interleukin-1beta, blueberry plants
8 authors
From IT, US
- Valentina TavernitiUniversity of Milan; University of Maine
- Daniela FracassettiUniversity of Milan; University of Maine
- Cristian Del Bo’University of Milan; University of Maine
- Claudia LantiUniversity of Milan; University of Maine
- Mario MinuzzoUniversity of Milan
- Dorothy J. Klimis‐ZacasUniversity of Maine
Abstract
Intestinal inflammation is a natural process crucial for the maintenance of gut functioning. However, abnormal or prolonged inflammatory responses may lead to the onset of chronic degenerative diseases, typically treated by means of pharmacological interventions. Dietary strategies for the prevention of inflammation are a safer alternative to pharmacotherapy. Anthocyanins and other polyphenols have been documented to display anti-inflammatory activity. In the present study, three bioactive fractions (anthocyanin, phenolic, and water-soluble fractions) were extracted from a wild blueberry powder. The Caco-2 intestinal model was used to test the immunomodulatory effect of the above fractions. Only the anthocyanin-rich fraction reduced the activation of NF-κB, induced by IL-1β in intestinal epithelial Caco-2 cells. Specifically, concentrations of 50 and 100 μg mL(-1) decreased NF-κB activation by 68.9 and 85.2%, respectively (p ≤ 0.05). These preliminary results provide further support for the role of food bioactives as potential dietary anti-inflammatory agents.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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