Rabbiteye blueberry prevents osteoporosis in ovariectomized rats
Li T, Wu SM, Xu ZY, Ou-Yang S
Journal of orthopaedic surgery and research · 19 citations
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2014-08-07 · J Orthop Surg Res · vol. 9 · issue 1 · p. 56
- Publisher
- BioMed Central
- Cited
- 30 citations · more than 62% of similar papers · 0.4× the field average
- References
- 32 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Bone Metabolism and Diseases · Bone health and osteoporosis research · Seaweed-derived Bioactive Compounds
- Keywords
- Ovariectomized rat, Osteoporosis, Medicine, Bone mineral, Osteoprotegerin, Bone resorption, Internal medicine, Endocrinology, Osteoclast, Bone remodeling, Receptor, Estrogen
- MeSH
- animals, humans, rats, sprague-dawley, osteoporosis, postmenopausal, disease models, animal, alkaline phosphatase, ovariectomy, bone density, female, osteoprotegerin, blueberry plants
4 authors
From CN
- Tao LiThird Affiliated Hospital of Southern Medical University
- Shou-Mian WuThird Affiliated Hospital of Southern Medical University; Southern Medical University
- Zhiyuan Xu · correspondingThird Affiliated Hospital of Southern Medical University; Southern Medical University
- Sheng Ouyang · correspondingThird Affiliated Hospital of Southern Medical University; Southern Medical University
Abstract
Objective
It has been forecasted that the rabbiteye blueberry could inhibit osteoporosis. However, the inhibition and prevention of osteoporosis via rabbiteye blueberry are still elusive. This study was aim to evaluate the anti-osteoporosis effects of rabbiteye blueberry in ovariectomized rats.
Methods
Thirty rats were randomly divided into three groups of ten rats each as follows: sham-operated group (SG), ovariectomized model control group (OMG), and ovariectomized rabbiteye blueberry treatment group (OBG). The blood mineral levels, the alkaline phosphatase (ALP) activity, and osteoprotegerin (OPG) level were determined. The expression analyses of type I collagen, integrin-β1, and focal adhesion kinase (FAK) were performed. Besides, the bone mineral density (BMD) and bone histomorphometry (BH) were measured.
Results
The ALP activity in SG and OBG was significantly lower than that in OMG. For the OPG level, the significant increase of OPG level in OBG was indicated compared with the other groups. The mRNA expression levels of type I collagen, integrin-β1, and FAK in OMG were significantly lower than those in other groups. The BMD in OMG were all significantly lower than those in SG and OBG. For BH, blueberry significantly improved the trabecular bone volume fraction, trabecular thickness, mean trabecular bone number, and bone formation rate, and decreased the trabecular separation, the percent of bone resorption perimeter, and mean osteoclast number in OBG compared with OMG.
Conclusions
The rabbiteye blueberries had an effective inhibition in bone resorption, bone loss, and reduction of bone strength of ovariectomized rats and could improve the BMD, osteogenic activity, and trabecular bone structure.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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