Dietary linoleic acid and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies
Farvid MS, Ding M, Pan A, Sun Q, Chiuve SE, Steffen LM, Willett WC, Hu FB
Circulation · 390 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Cancer Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NCI NIH HHS
- Government
- NIDDK NIH HHS
- Government
- NHLBI NIH HHS
- Grants
- National Heart, Lung, and Blood Institute (HL60712); National Cancer Institute (U01 CA167552); National Cancer Institute (P01 CA055075.); National Cancer Institute (UM1-CA-167552); National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK058845); National Heart, Lung, and Blood Institute (R01 HL060712)
Based on 6 listed funder(s).
Publication
- Published
- 2014-08-27 · Circulation · vol. 130 · issue 18 · pp. 1568–1578
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 564 citations · more than 97% of similar papers · 6.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 48 works
- Access
- Open access (repository copy)
- Research areas
- Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress · Liver Disease Diagnosis and Treatment
- Keywords
- Medicine, Coronary heart disease, Meta-analysis, Prospective cohort study, Linoleic acid, Cohort study, Internal medicine, Cardiology, Fatty acid
- MeSH
- humans, coronary disease, dietary fats, linoleic acid, risk factors, prospective studies, observational studies as topic
8 authors
From US, SG, IR
- Maryam Sadat FarvidBrigham and Women's Hospital; University of Minnesota; Harvard University; National University of Singapore; National Nutrition and Food Technology Research Institute; National University Health System; Shahid Beheshti University of Medical Sciences
- Ming DingBrigham and Women's Hospital; University of Minnesota; Harvard University; National University of Singapore; National Nutrition and Food Technology Research Institute; National University Health System; Shahid Beheshti University of Medical Sciences
- An PanBrigham and Women's Hospital; University of Minnesota; Harvard University; National University of Singapore; National Nutrition and Food Technology Research Institute; National University Health System; Shahid Beheshti University of Medical Sciences
- Qi SunBrigham and Women's Hospital; University of Minnesota; Harvard University; National University of Singapore; National Nutrition and Food Technology Research Institute; National University Health System; Shahid Beheshti University of Medical Sciences
- Stephanie E. ChiuveBrigham and Women's Hospital; University of Minnesota; Harvard University; National University of Singapore; National Nutrition and Food Technology Research Institute; National University Health System; Shahid Beheshti University of Medical Sciences
- Lyn M. SteffenBrigham and Women's Hospital; University of Minnesota; Harvard University; National University of Singapore; National Nutrition and Food Technology Research Institute; National University Health System; Shahid Beheshti University of Medical Sciences
Abstract
Background
Previous studies on intake of linoleic acid (LA), the predominant n-6 fatty acid, and coronary heart disease (CHD) risk have generated inconsistent results. We performed a systematic review and meta-analysis of prospective cohort studies to summarize the evidence regarding the relation of dietary LA intake and CHD risk.
Methods and results
We searched MEDLINE and EMBASE databases through June 2013 for prospective cohort studies that reported the association between dietary LA and CHD events. In addition, we used unpublished data from cohort studies in a previous pooling project. We pooled the multivariate-adjusted relative risk (RR) to compare the highest with the lowest categories of LA intake using fixed-effect meta-analysis. We identified 13 published and unpublished cohort studies with a total of 310 602 individuals and 12 479 total CHD events, including 5882 CHD deaths. When the highest category was compared with the lowest category, dietary LA was associated with a 15% lower risk of CHD events (pooled RR, 0.85; 95% confidence intervals, 0.78-0.92; I(2)=35.5%) and a 21% lower risk of CHD deaths (pooled RR, 0.79; 95% confidence intervals, 0.71-0.89; I(2)=0.0%). A 5% of energy increment in LA intake replacing energy from saturated fat intake was associated with a 9% lower risk of CHD events (RR, 0.91; 95% confidence intervals, 0.87-0.96) and a 13% lower risk of CHD deaths (RR, 0.87; 95% confidence intervals, 0.82-0.94).
Conclusions
In prospective observational studies, dietary LA intake is inversely associated with CHD risk in a dose-response manner. These data provide support for current recommendations to replace saturated fat with polyunsaturated fat for primary prevention of CHD.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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