Differential acute postprandial effects of processed meat and isocaloric vegan meals on the gastrointestinal hormone response in subjects suffering from type 2 diabetes and healthy controls: a randomized crossover study
Belinova L, Kahleova H, Malinska H, Topolcan O, Vrzalova J, Oliyarnyk O, Kazdova L, Hill M, Pelikanova T
PloS one · 36 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- University or hospital
- Univerzita Karlova v Praze
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2014-09-15 · PLoS One · vol. 9 · issue 9 · p. e107561
- Publisher
- Public Library of Science
- Cited
- 47 citations · more than 73% of similar papers · 1.1× the field average
- References
- 56 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Regulation of Appetite and Obesity · Diet and metabolism studies · Nutritional Studies and Diet
- Keywords
- Postprandial, Internal medicine, Crossover study, Meal, Type 2 diabetes, Medicine, Endocrinology, Insulin, Diabetes mellitus, Incretin, Placebo
- MeSH
- humans, diabetes mellitus, type 2, gastrointestinal hormones, gastric inhibitory polypeptide, insulin, blood glucose, lipids, triglycerides, postprandial period, food handling, meat, middle aged, female, male, glucagon-like peptide 1, ghrelin, diet, vegan
9 authors
From CZ
- Lenka Belinova · correspondingCharles University; Institute of Clinical and Experimental Medicine
- Hana KahleováInstitute of Clinical and Experimental Medicine
- Hana MalínskáInstitute of Clinical and Experimental Medicine
- Ondřej Topolčan
- Jindra Vrzalová
- Olena OliyarnykInstitute of Clinical and Experimental Medicine
Abstract
Background
The intake of meat, particularly processed meat, is a dietary risk factor for diabetes. Meat intake impairs insulin sensitivity and leads to increased oxidative stress. However, its effect on postprandial gastrointestinal hormone (GIH) secretion is unclear. We aimed to investigate the acute effects of two standardized isocaloric meals: a processed hamburger meat meal rich in protein and saturated fat (M-meal) and a vegan meal rich in carbohydrates (V-meal). We hypothesized that the meat meal would lead to abnormal postprandial increases in plasma lipids and oxidative stress markers and impaired GIH responses.
Methods
In a randomized crossover study, 50 patients suffering from type 2 diabetes (T2D) and 50 healthy subjects underwent two 3-h meal tolerance tests. For statistical analyses, repeated-measures ANOVA was performed.
Results
The M-meal resulted in a higher postprandial increase in lipids in both groups (p<0.001) and persistent postprandial hyperinsulinemia in patients with diabetes (p<0.001). The plasma glucose levels were significantly higher after the V-meal only at the peak level. The plasma concentrations of glucose-dependent insulinotropic peptide (GIP), peptide tyrosine-tyrosine (PYY) and pancreatic polypeptide (PP) were higher (p<0.05, p<0.001, p<0.001, respectively) and the ghrelin concentration was lower (p<0.001) after the M-meal in healthy subjects. In contrast, the concentrations of GIP, PYY and PP were significantly lower after the M-meal in T2D patients (p<0.001). Compared with the V-meal, the M-meal was associated with a larger increase in lipoperoxidation in T2D patients (p<0.05).
Conclusion/interpretation
Our results suggest that the diet composition and the energy content, rather than the carbohydrate count, should be important considerations for dietary management and demonstrate that processed meat consumption is accompanied by impaired GIH responses and increased oxidative stress marker levels in diabetic patients.
Trial registration
ClinicalTrials.gov NCT01572402.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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