Cholesterol and egg intakes and the risk of type 2 diabetes: the Japan Public Health Center-based Prospective Study
Kurotani K, Nanri A, Goto A, Mizoue T, Noda M, Oba S, Sawada N, Tsugane S, Japan Public Health Center-based Prospective Study Group
The British journal of nutrition · 34 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- National Center for Global Health and Medicine
- Government
- Ministry of Health, Labour and Welfare
- University or hospital
- Tokyo University of Agriculture
- University or hospital
- Tokyo Medical and Dental University
- Government
- Japan Society for the Promotion of Science
- Grants
- Ministry of Health, Labour and Welfare (H19‐016); Ministry of Health, Labour and Welfare (19shi-2); Japan Society for the Promotion of Science (25871168)
Based on 5 listed funder(s).
Publication
- Published
- 2014-09-18 · Br J Nutr · vol. 112 · issue 10 · pp. 1636–1643
- Publisher
- Cambridge University Press
- Cited
- 42 citations · more than 94% of similar papers · 4.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 30 works
- Access
- Free to read
- Research areas
- Nutritional Studies and Diet · Diet and metabolism studies · Diet, Metabolism, and Disease
- Keywords
- Medicine, Quartile, Type 2 diabetes, Diabetes mellitus, Prospective cohort study, Odds ratio, Cholesterol, Logistic regression, Internal medicine, Risk factor, Endocrinology, Confidence interval
- MeSH
- humans, diabetes mellitus, type 2, cholesterol, dietary, diet, logistic models, odds ratio, risk factors, prospective studies, sex factors, postmenopause, eggs, adult, middle aged, japan, female, male, self report, surveys and questionnaires
8 authors
From JP, US
- Kayo Kurotani · correspondingNational Center for Global Health and Medicine
- Akiko NanriNational Center for Global Health and Medicine
- Atsushi GotoNational Center for Global Health and Medicine
- Tetsuya MizoueNational Center for Global Health and Medicine
- Mitsuhiko NodaNational Center for Global Health and Medicine
- Shino ObaNational Institute of Public Health
Abstract
Limited and inconsistent associations between cholesterol and egg consumption and type 2 diabetes risk have been observed in Western countries. In the present study, the association of dietary cholesterol and egg intakes with type 2 diabetes risk was examined prospectively. The study subjects comprised 27, 248 men and 36,218 women aged 45-75 years who participated in the second survey of the Japan Public Health Center-based Prospective Study and had no histories of type 2 diabetes or other serious diseases. Dietary cholesterol and egg intakes were estimated using a validated 147-item FFQ. The OR of self-reported, physician-diagnosed type 2 diabetes over 5 years were estimated using multiple logistic regression. A total of 1165 newly diagnosed cases of type 2 diabetes were self-reported. Although dietary cholesterol intake was not associated with type 2 diabetes risk in men, it was found to be associated with a 23 % lower odds of type 2 diabetes risk in women in the highest quartile of intake, albeit not statistically significant, compared with those in the lowest quartile (P trend= 0·08). Such risk reduction was somewhat greater among postmenopausal women; the multivariable-adjusted OR for the highest quartile of cholesterol intake compared with the lowest quartile was 0·68 (95 % CI 0·49, 0·94; P trend= 0·04). No association between egg intake and type 2 diabetes risk was found in either men or women. In conclusion, higher intake of cholesterol or eggs may not be associated with an increased risk of type 2 diabetes in Japanese populations. The observed association between decreased type 2 diabetes risk and higher dietary cholesterol intake in postmenopausal women warrants further investigation.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.