Withanone-rich combination of Ashwagandha withanolides restricts metastasis and angiogenesis through hnRNP-K
Gao R, Shah N, Lee JS, Katiyar SP, Li L, Oh E, Sundar D, Yun CO, Wadhwa R, Kaul SC
Molecular cancer therapeutics · 52 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- National Institute of Biomedical Innovation
Based on 1 listed funder(s).
Publication
- Published
- 2014-09-19 · Mol Cancer Ther · vol. 13 · issue 12 · pp. 2930–2940
- Publisher
- American Association for Cancer Research
- Cited
- 72 citations · more than 99% of similar papers · 15.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 49 works
- Access
- Paywalled
- Research areas
- Phytochemicals and Medicinal Plants · Computational Drug Discovery Methods · Viral Infectious Diseases and Gene Expression in Insects
- Keywords
- Withaferin A, Angiogenesis, In vivo, Cancer, Traditional medicine, Downregulation and upregulation, Herb, Metastasis, Pharmacology, Biology, Cancer cell, In vitro, Withania somnifera, Medicinal herbs, Cancer research, Medicine, Biochemistry, Biotechnology, Gene, Genetics
- MeSH
- cell line, tumor, animals, humans, mice, neoplasms, neoplasm metastasis, disease models, animal, neovascularization, pathologic, triterpenes, heterogeneous-nuclear ribonucleoprotein k, plant extracts, antineoplastic agents, phytogenic, tumor burden, reproducibility of results, xenograft model antitumor assays, cell proliferation, cell movement, molecular conformation, models, molecular, withanolides, human umbilical vein endothelial cells
10 authors
From JP, KR, IN
- Ran GaoNational Institute of Advanced Industrial Science and Technology
- Navjot ShahNational Institute of Advanced Industrial Science and Technology
- Jung‐Sun LeeHanyang University; Anyang University
- Shashank Prakash KatiyarIndian Institute of Technology Delhi
- Ling LiNational Institute of Advanced Industrial Science and Technology
- Eonju OhHanyang University; Anyang University
Abstract
Ashwagandha is an important herb used in the Indian system of traditional home medicine, Ayurveda. Alcoholic extract (i-Extract) from its leaves and its component, withanone, were previously shown to possess anticancer activity. In the present study, we developed a combination of withanone and withaferin A, major withanolides in the i-Extract, that retained the selective cancer cell killing activity and found that it also has significant antimigratory, -invasive, and -angiogenic activities, in both in vitro and in vivo assays. Using bioinformatics and biochemical approaches, we demonstrate that these phytochemicals caused downregulation of migration-promoting proteins hnRNP-K, VEGF, and metalloproteases and hence are candidate natural drugs for metastatic cancer therapy.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.