The influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults: a randomized crossover intervention trial
Foerster J, Maskarinec G, Reichardt N, Tett A, Narbad A, Blaut M, Boeing H
PloS one · 64 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Government
- European Commission
- Government
- Biotechnology and Biological Sciences Research Council
- Government
- National Cancer Institute
- Government
- FP7 Food, Agriculture and Fisheries, Biotechnology
- Government
- NCI NIH HHS
- Grants
- European Commission (222720); National Cancer Institute (P30CA071789); Biotechnology and Biological Sciences Research Council (BBS/E/F/00042572); Biotechnology and Biological Sciences Research Council (BBS/E/F/00042572)
Based on 5 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2014-10-09 · PLoS One · vol. 9 · issue 10 · p. e109606
- Publisher
- Public Library of Science
- Cited
- 76 citations · more than 83% of similar papers · 1.6× the field average
- References
- 44 works
- Access
- Open access (journal) · PUBLIC-DOMAIN
- Research areas
- Gut microbiota and health · Diet and metabolism studies · Nutritional Studies and Diet
- Keywords
- Gut flora, Crossover study, Medicine, Overweight, Obesity, Anthropometry, White meat, Logistic regression, Internal medicine, Food science, Biology, Placebo, Immunology, Pathology
- MeSH
- feces, humans, clostridium, actinobacteria, body weight, creatinine, uric acid, rna, ribosomal, 16s, bacterial typing techniques, diet, logistic models, prospective studies, cross-over studies, adult, middle aged, female, male, gastrointestinal microbiome, whole grains, red meat
7 authors
From DE, US, GB
- Jana Foerster · correspondingGerman Institute of Human Nutrition
- Gertraud MaskarinecUniversity of Hawaiʻi at Mānoa; University of Hawaii System; Cancer Center of Hawaii; German Institute of Human Nutrition; University of Hawaii Cancer Center
- Nicole ReichardtNorwich Research Park; Quadram Institute
- Adrian TettNorwich Research Park; Quadram Institute
- Arjan NarbadNorwich Research Park; Quadram Institute
- Michaël BlautGerman Institute of Human Nutrition
Abstract
Intestinal microbiota is related to obesity and serum lipid levels, both risk factors for chronic diseases constituting a challenge for public health. We investigated how a diet rich in whole grain (WG) products and red meat (RM) influences microbiota. During a 10-week crossover intervention study, 20 healthy adults consumed two isocaloric diets, one rich in WG products and one high in RM. Repeatedly data on microbiota were assessed by 16S rRNA based denaturing gradient gel electrophoresis (DGGE). A blood sample and anthropometric data were collected. Mixed models and logistic regression were used to investigate effects. Microbiota showed interindividual variability. However, dietary interventions modified microbiota appearance: 8 bands changed in at least 4 participants during the interventions. One of the bands appearing after WG and one increasing after RM remained significant in regression models and were identified as Collinsella aerofaciens and Clostridium sp. The WG intervention lowered obesity parameters, while the RM diet increased serum levels of uric acid and creatinine. The study showed that diet is a component of major relevance regarding its influence on intestinal microbiota and that WG has an important role for health. The results could guide investigations of diet and microbiota in observational prospective cohort studies. Trial registration: ClinicalTrials.gov NCT01449383.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC0).
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