Dietary nitrate accelerates postexercise muscle metabolic recovery and O2 delivery in hypoxia
Vanhatalo A, Jones AM, Blackwell JR, Winyard PG, Fulford J
Journal of applied physiology (Bethesda, Md. : 1985) · 35 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2014-10-10 · J Appl Physiol (1985) · vol. 117 · issue 12 · pp. 1460–1470
- Publisher
- American Physiological Society
- Cited
- 40 citations · more than 98% of similar papers · 13.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 70 works
- Access
- Open access (repository copy)
- Research areas
- Cardiovascular and exercise physiology · High Altitude and Hypoxia · Advanced MRI Techniques and Applications
- Keywords
- Hypoxia (environmental), Animal science, Crossover study, Chemistry, Endocrinology, Internal medicine, Phosphocreatine, Placebo, Oxygen, Medicine, Biology, Energy metabolism, Pathology
- MeSH
- muscle, skeletal, mitochondria, muscle, humans, beta vulgaris, plant roots, nitrates, nitrites, oxygen, nitric oxide, phosphocreatine, adenosine triphosphate, plant preparations, magnetic resonance imaging, magnetic resonance spectroscopy, diet, administration, oral, cross-over studies, double-blind method, recovery of function, energy metabolism, oxygen consumption, muscle contraction, kinetics, beverages, adolescent, adult, england, female, male, young adult, biomarkers, hypoxia
5 authors
From GB
- Anni Vanhatalo · correspondingUniversity of Exeter
- ANDREW MARK JONESUniversity of Exeter
- Jamie R. BlackwellUniversity of Exeter
- Paul Graham WinyardUniversity of Exeter
- Jonathan FulfordNIHR Exeter Clinical Research Facility
Abstract
We tested the hypothesis that the time constants (τ) of postexercise T2* MRI signal intensity (an index of O2 delivery) and muscle [PCr] (an index of metabolic perturbation, measured by (31)P-MRS) in hypoxia would be accelerated after dietary nitrate (NO3 (-)) supplementation. In a double-blind crossover design, eight moderately trained subjects underwent 5 days of NO3 (-) (beetroot juice, BR; 8.2 mmol/day NO3 (-)) and placebo (PL; 0.003 mmol/day NO3 (-)) supplementation in four conditions: normoxic PL (N-PL), hypoxic PL (H-PL; 13% O2), normoxic NO3 (-) (N-BR), and hypoxic NO3 (-) (H-BR). The single-leg knee-extension protocol consisted of 10 min of steady-state exercise and 24 s of high-intensity exercise. The [PCr] recovery τ was greater in H-PL (30 ± 4 s) than H-BR (22 ± 4 s), N-PL (24 ± 4 s) and N-BR (22 ± 4 s) (P 0.05). These findings suggest that the NO3 (-)-NO2 (-)-NO pathway is a significant modulator of muscle energetics and O2 delivery during hypoxic exercise and subsequent recovery.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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