Red meat intake, insulin resistance, and markers of endothelial function among Iranian women
Barak F, Falahi E, Keshteli AH, Yazdannik A, Saneei P, Esmaillzadeh A
Molecular nutrition & food research · 25 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- University or hospital
- Isfahan University of Medical Sciences
- University or hospital
- Food Security Research Center
Based on 2 listed funder(s).
Publication
- Published
- 2014-10-14 · Mol Nutr Food Res · vol. 59 · issue 2 · pp. 315–322
- Publisher
- Wiley
- Cited
- 30 citations · more than 86% of similar papers · 1.9× the field average
- References
- 38 works
- Access
- Paywalled
- Research areas
- Nutritional Studies and Diet · Agriculture Sustainability and Environmental Impact · Meat and Animal Product Quality
- Keywords
- Insulin resistance, Red meat, Insulin, Medicine, Confounding, Glycemic index, Endothelial dysfunction, Internal medicine, Homeostatic model assessment, Food science, Endocrinology, Physiology, Glycemic, Biology, Pathology
- MeSH
- endothelium, humans, insulin resistance, insulin, blood glucose, intercellular adhesion molecule-1, e-selectin, vascular cell adhesion molecule-1, body mass index, nutrition assessment, linear models, cross-sectional studies, energy intake, homeostasis, meat, meat products, adult, iran, female, insulin-secreting cells, fast foods, biomarkers
6 authors
From IR, CA
- Farzaneh BarakIsfahan University of Medical Sciences
- Ebrahim FalahiLorestan University of Medical Sciences
- Ammar Hassanzadeh KeshteliUniversity of Alberta
- Ahmadreza YazdannikIsfahan University of Medical Sciences; Iranshahr University
- Parvane SaneeiIsfahan University of Medical Sciences
- Ahmad Esmaillzadeh · correspondingIsfahan University of Medical Sciences
Abstract
Scope
Few data, with conflicting findings, are available linking red meat consumption to indicators of insulin resistance and endothelial dysfunction. This study aimed to investigate the association of red meat consumption with insulin resistance and endothelial dysfunction among a sample of female nurses in Isfahan, Iran.
Methods and results
This cross-sectional study was carried out among 420 female nurses who were selected by a multistage cluster random sampling method. Usual dietary intakes were assessed using a validated food frequency questionnaire. Red meat intake was calculated by summing up the consumption of all kinds of red meat in foods and processed meat in sausages and fast foods. To measure serum concentrations of adhesion molecules and glycemic indexes, a fasting blood sample was taken. After adjustment for potential confounders, high red meat intake was significantly associated with higher fasting plasma glucose, homeostasis model assessment of insulin resistance, and lower quantitative insulin sensitivity check index. Although high red meat intake was significantly associated with higher serum insulin levels and lower homeostasis model assessment of beta-cell function in the crude model, after controlling for BMI, the association was no longer significant. Red meat consumption was associated with high concentrations of E-selectin, soluble vascular cell adhesion molecule-1 (sVCAM-1), and soluble intercellular adhesion molecule-1 (sICAM-1) after adjustment for different potential confounders.
Conclusion
We found that increased red meat intake was associated with high concentrations of plasma endothelial dysfunction biomarkers and abnormal glucose homeostasis among Iranian women. Prospective studies are required to confirm these findings.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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