Whole grain rye intake, reflected by a biomarker, is associated with favorable blood lipid outcomes in subjects with the metabolic syndrome--a randomized study
Magnusdottir OK, Landberg R, Gunnarsdottir I, Cloetens L, Åkesson B, Rosqvist F, Schwab U, Herzig KH, Hukkanen J, Savolainen MJ, Brader L, Hermansen K, Kolehmainen M, Poutanen K, Uusitupa M, Risérus U, Thorsdottir I
PloS one · 31 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Intake biomarkers
Who paid for it
- Funding
- Possibly industry funded
- Government
- Strategiske Forskningsråd
- Nonprofit
- Foundation for Cardiovascular Research
- Government
- Academy of Finland
- University or hospital
- Kuopion Yliopistollinen Sairaala
- Government
- Vetenskapsrådet
- Government
- NordForsk
- Nonprofit
- Sydäntutkimussäätiö
- Government
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd
- Nonprofit
- European Society for Clinical Nutrition and Metabolism
- Nonprofit
- Diabetesfonden
- Nonprofit
- Diabetestutkimussäätiö
- Grants
- NordForsk (070014)); Academy of Finland (070014)
Based on 11 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2014-10-23 · PLoS One · vol. 9 · issue 10 · p. e110827
- Publisher
- Public Library of Science
- Cited
- 54 citations · more than 91% of similar papers · 3.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 42 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Food composition and properties · Liver Disease Diagnosis and Treatment · Metabolomics and Mass Spectrometry Studies
- Keywords
- Body mass index, Confounding, Medicine, Blood lipids, Population, Cholesterol, Lipid profile, Biomarker, Refined grains, Whole grains, Internal medicine, Animal science, Food science, Biology, Biochemistry
- MeSH
- humans, resorcinols, cholesterol, lipids, body mass index, diet, adult, aged, middle aged, female, male, biomarkers, secale, whole grains, metabolic syndrome
17 authors
From IS, SE, FI, DK
- Óla Kallý Magnúsdóttir · correspondingUniversity of Iceland; National University Hospital of Iceland
- Rikard LandbergKarolinska Institutet; Swedish University of Agricultural Sciences
- Ingibjörg GunnarsdóttirUniversity of Iceland; National University Hospital of Iceland
- Lieselotte CloetensLund University
- Björn ÅkessonLund University; Skåne University Hospital
- Fredrik RosqvistUppsala University
Abstract
Background and aim
Few studies have explored the possible plasma cholesterol lowering effects of rye consumption. The aim of this secondary analysis in the SYSDIET study was to investigate the association between plasma alkylresorcinols (AR), a biomarker for whole grain wheat and rye intake, and blood lipid concentrations in a population with metabolic syndrome. Furthermore, we analyzed the associations between the AR C17:0/C21:0 ratio, a suggested marker of the relative intake of whole grain/bran rye, and blood lipid concentrations.
Methods
Participants were 30-65 years of age, with body mass index (BMI) 27-40 kg/m2 and had metabolic syndrome. Individuals were recruited through six centers in the Nordic countries and randomized either to a healthy Nordic diet (ND, n = 93), rich in whole grain rye and wheat, as well as berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products, or a control diet (n = 65) for 18/24 weeks. Associations between total plasma AR concentration and C17:0/C21:0 homologue ratio and blood lipids were investigated in pooled (ND + control group) regression analyses at 18/24 weeks adjusted for baseline value for the dependent variable, age, BMI and statin use.
Results
When adjusted for confounders, total plasma AR at 18/24 weeks was not significantly associated with blood lipids but the AR ratio C17:0/C21:0 was inversely associated with LDL cholesterol concentrations (B (95% CI): -0.41 (-0.80 to -0.02)), log LDL/HDL cholesterol ratio (-0.20 (-0.37 to -0.03)), log non-HDL cholesterol (-0.20 (-0.37 to -0.03)), log apolipoprotein B (-0.12 (-0.24 to 0.00)) and log triglyceride concentrations (-0.35 (-0.59 to -0.12)).
Discussion
Increased proportion of whole grain rye, reflected by a biomarker, in the diet is associated with favorable blood lipid outcomes, a relationship that should be further investigated.
Trial registration
ClinicalTrials.gov NCT00992641.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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