Funded in part by Union zur Förderung von Oel- und Proteinpflanzen e. V., Germany
Dietary rapeseed/canola-oil supplementation reduces serum lipids and liver enzymes and alters postprandial inflammatory responses in adipose tissue compared to olive-oil supplementation in obese men
Kruse M, von Loeffelholz C, Hoffmann D, Pohlmann A, Seltmann AC, Osterhoff M, Hornemann S, Pivovarova O, Rohn S, Jahreis G, Pfeiffer AF
Molecular nutrition & food research · 60 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Industry funded
- Industry group
- Union zur Förderung von Oel- und Proteinpflanzen e. V., Germany
Based on 1 listed funder(s).
Publication
- Published
- 2014-11-18 · Mol Nutr Food Res · vol. 59 · issue 3 · pp. 507–519
- Publisher
- Wiley
- Cited
- 80 citations · more than 94% of similar papers · 4.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 55 works
- Access
- Paywalled
- Research areas
- Fatty Acid Research and Health · Nuts composition and effects · Edible Oils Quality and Analysis
- Keywords
- Adipose tissue, Internal medicine, Endocrinology, Blood lipids, White adipose tissue, Hyperlipidemia, Polyunsaturated fatty acid, Inflammation, Canola, Cholesterol, Medicine, Biology, Biochemistry, Fatty acid, Food science
- MeSH
- liver, adipose tissue, humans, panniculitis, obesity, insulin, blood glucose, lipids, fatty acids, monounsaturated, plant oils, interleukin-6, gene expression regulation, body composition, postprandial period, dietary supplements, adult, middle aged, male, chemokine ccl2, rapeseed oil
11 authors
From DE
- Michael W. KruseGerman Institute of Human Nutrition; Charité - Universitätsmedizin Berlin
- Christian von LoeffelholzJena University Hospital; German Institute of Human Nutrition; Center for Sepsis Control and Care; Charité - Universitätsmedizin Berlin
- Daniela HoffmannGerman Institute of Human Nutrition
- Antje PohlmannGerman Institute of Human Nutrition
- Anne‐Cathrin SeltmannGerman Institute of Human Nutrition
- Martin A. OsterhoffGerman Institute of Human Nutrition; Charité - Universitätsmedizin Berlin
Abstract
Scope
Obesity is associated with hyperlipidemia, hepatic steatosis, and low-grade inflammation. Studies have shown that MUFA as well as PUFA have beneficial effects on blood lipids and the inflammatory state.
Methods and results
This study investigates the effects of a daily supplementation of either 50 g of rapeseed/canola (RA) or olive (OL) oil over 4 wk on serum lipids, serum liver enzymes, and inflammatory gene expression in subcutaneous (s. c.) adipose tissue in obese men. Consuming RA resulted in increased serum n-3 fatty acids and a reduction in total cholesterol, LDL cholesterol, and serum aspartate aminotransferase compared to OL. In s. c. adipose tissue, gene expression of the pro-inflammatory cytokine IL6 was reduced in RA compared to OL. However, after 4 h after a test meal, containing the appropriate oil, white bread, and 400 mL of liquid diet drink (835 kcal in total), gene expression of IL6, IL1B, and EMR1 (egf-like module containing Mucin-like hormone receptor-like 1) was increased in RA and of monocyte chemoattractant protein-1 (CCL2) in both RA and OL.
Conclusion
This demonstrates that consuming RA for 4 wk improves serum lipids, liver enzymes, and basal inflammation in s. c. adipose tissue, but it mediates an acute pro-inflammatory response in adipose tissue upon consuming a meal.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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