Olive oil in the prevention and treatment of osteoporosis after artificial menopause
Liu H, Huang H, Li B, Wu D, Wang F, Zheng Xh, Chen Q, Wu B, Fan X
Clinical interventions in aging · 35 citations
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2014-12-01 · Clin Interv Aging · vol. 9 · p. 2087
- Publisher
- Dove Medical Press
- Cited
- 43 citations · more than 70% of similar papers · 0.8× the field average
- References
- 43 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Edible Oils Quality and Analysis · Menopause: Health Impacts and Treatments · Fatty Acid Research and Health
- Keywords
- Medicine, Menopause, Osteoporosis, Internal medicine, Intensive care medicine
- MeSH
- animals, humans, rats, rats, sprague-dawley, osteoporosis, postmenopausal, nitrates, calcium, phosphorus, malondialdehyde, plant oils, alpha-fetoproteins, carcinoembryonic antigen, anti-inflammatory agents, antigens, tumor-associated, carbohydrate, interleukin-6, estrogens, antioxidants, absorptiometry, photon, bone density, female, olive oil
9 authors
From CN
- Huilan LiuXiamen University
- Huijuan HuangXiamen University
- Baoheng LiXiamen University
- Wu DongXiamen University
- Fengmei WangXiamen University
- Xiaohua ZhengXiamen University
Abstract
Purpose
The goal of this study was to investigate the anti-osteoporosis effect of extra virgin olive oil (EVOO) in vivo, and explore its antioxidant, anti-inflammatory properties in Sprague Dawley rats and its anticancer properties in patients.
Materials and methods
A total of 120 healthy female Sprague Dawley rats aged 6 months were divided into four groups: 1) sham-operated control (Sham group, n=30); 2) ovariectomized (OVX group, n=30); 3) ovariectomized rats supplemented with EVOO (OVX + Olive, n=30); 4) ovariectomized rats supplemented with estrogen (OVX + E2, n=30). EVOO and estrogen were administered by oral gavage at a dose of 1 mL/100 g weight on a daily basis for 12 consecutive weeks. Twelve weeks later blood samples were obtained to detect the levels of calcium, alkaline phosphatase, phosphorus, interleukin-6 (IL-6), malonyldialdehyde (MDA), and nitrate content. Dual energy X-ray absorptiometer measured bone mineral density (BMD) of ovariectomized Sprague Dawley rats that had been fed olive oil for 3 months. Blood samples from patients, who regularly consumed olive oil over a 1 year period were also used to measure carbohydrate antigen 125, carcino-embryonic antigen, α-fetoprotein, and carbohydrate antigen 19-9 levels. BMD of lumbar spine and left femur was also evaluated by dual energy X-ray absorptiometry.
Results
Animal experiments showed that EVOO significantly increased BMD and decreased phosphatase, alkaline phosphatase, IL-6, MDA, and nitrate levels. However, it had no significant effect on the Ca(2+) level. In clinical follow-up, EVOO also improved patient BMD levels on L3, L4, and left femoral neck, and reduced carbohydrate antigen 125, α-fetoprotein, and carcino-embryonic antigen levels. But it had no significant effect on the carbohydrate antigen 19-9 level.
Conclusion
EVOO illustrated significant anti-osteoporosis, antioxidant, anti-inflammatory, and anticancer properties in vivo. However, further studies are required to determine the active component(s) responsible for these effects.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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