Dietary magnesium intake and metabolic syndrome in the adult population: dose-response meta-analysis and meta-regression
Ju SY, Choi WS, Ock SM, Kim CM, Kim DH
Nutrients · 45 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- University or hospital
- Catholic University of Korea
- University or hospital
- College of Medicine, Catholic University of Korea
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2014-12-22 · Nutrients · vol. 6 · issue 12 · pp. 6005–6019
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 69 citations · more than 92% of similar papers · 3.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 66 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Therapeutic Uses of Natural Elements · Parathyroid Disorders and Treatments
- Keywords
- Meta-analysis, Meta-regression, Medicine, Magnesium, Population, Physiology, Metabolic syndrome, Internal medicine, Endocrinology, Biology, Food science, Obesity, Environmental health, Chemistry
- MeSH
- humans, magnesium, risk assessment, risk factors, dose-response relationship, drug, observational studies as topic, metabolic syndrome
5 authors
From KR, US, GB
- Sang-Yhun JuThe Catholic University of Korea Yeouido St. Mary's Hospital; Catholic University of Korea
- Whan-Seok ChoiSt. Mary's Hospital; St Mary's Hospital; The Catholic University of Korea Seoul St. Mary's Hospital; Catholic University of Korea
- Sun-Myeong OckThe Catholic University of Korea Yeouido St. Mary's Hospital
- Chul-Min KimSt. Mary's Hospital; St Mary's Hospital; The Catholic University of Korea Seoul St. Mary's Hospital
- Do‐Hoon KimKorea University; Ansan University; Korea University Ansan Hospital
Abstract
ncreasing evidence has suggested an association between dietary magnesium intake and metabolic syndrome. However, previous research examining dietary magnesium intake and metabolic syndrome has produced mixed results. Our objective was to determine the relationship between dietary magnesium intake and metabolic syndrome in the adult population using a dose-response meta-analysis. We searched the PubMed, Embase and the Cochrane Library databases from August, 1965, to May, 2014. Observational studies reporting risk ratios with 95% confidence intervals (CIs) for metabolic syndrome in ≥ 3 categories of dietary magnesium intake levels were selected. The data extraction was performed independently by two authors, and the quality of the studies was evaluated using the Risk of Bias Assessment Tool for Nonrandomized Studies (RoBANS). Based on eight cross-sectional studies and two prospective cohort studies, the pooled relative risks of metabolic syndrome per 150 mg/day increment in magnesium intake was 0.88 (95% CI, 0.84-0.93; I(2) = 36.3%). The meta-regression model showed a generally linear, inverse relationship between magnesium intake (mg/day) and metabolic syndrome. This dose-response meta-analysis indicates that dietary magnesium intake is significantly and inversely associated with the risk of metabolic syndrome. However, randomized clinical trials will be necessary to address the issue of causality and to determine whether magnesium supplementation is effective for the prevention of metabolic syndrome.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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