Acute dietary nitrate supplementation does not augment submaximal forearm exercise hyperemia in healthy young men
Kim JK, Moore DJ, Maurer DG, Kim-Shapiro DB, Basu S, Flanagan MP, Skulas-Ray AC, Kris-Etherton P, Proctor DN
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 37 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- University or hospital
- Social Science Research Institute, Pennsylvania State University
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Center for Research Resources
- Government
- National Center for Advancing Translational Sciences
- Government
- NHLBI NIH HHS
- Government
- NCATS NIH HHS
- Grants
- National Heart, Lung, and Blood Institute (HL058091); National Center for Advancing Translational Sciences (UL1-TR000127); National Heart, Lung, and Blood Institute (R37HL058091); National Heart, Lung, and Blood Institute (R29 HL058091); National Heart, Lung, and Blood Institute (R01 HL058091)
Based on 7 listed funder(s).
Publication
- Published
- 2014-10-15 · Appl Physiol Nutr Metab · vol. 40 · issue 2 · pp. 122–128
- Publisher
- NRC Research Press
- Cited
- 46 citations · more than 86% of similar papers · 1.9× the field average
- References
- 42 works
- Access
- Open access (repository copy)
- Research areas
- Heart Rate Variability and Autonomic Control · Cardiovascular Health and Disease Prevention · Cardiovascular and exercise physiology
- Keywords
- Brachial artery, Arterial stiffness, Medicine, Pulse wave velocity, Crossover study, Nitrate, Placebo, Vasodilation, Reactive hyperemia, Internal medicine, Cardiology, Radial artery, Forearm, Blood pressure, Endocrinology, Artery, Surgery, Chemistry, Pathology
- MeSH
- forearm, humans, beta vulgaris, plant roots, hyperemia, nitrates, plant extracts, hand strength, exercise, cross-over studies, double-blind method, reference values, beverages, dietary supplements, adult, male, young adult
9 authors
From US
- Jin‐Kwang KimPennsylvania State University
- David J. MoorePennsylvania State University
- David G. MaurerPennsylvania State University
- Daniel B. Kim‐ShapiroWake Forest University
- Swati BasuWake Forest University
- Michael Patrick FlanaganPenn State Milton S. Hershey Medical Center
Abstract
Despite the popularity of dietary nitrate supplementation and the growing evidence base of its potential ergogenic and vascular health benefits, there is no direct information about its effects on exercising limb blood flow in humans. We hypothesized that acute dietary nitrate supplementation from beetroot juice would augment the increases in forearm blood flow, as well as the progressive dilation of the brachial artery, during graded handgrip exercise in healthy young men. In a randomized, double-blind, placebo-controlled crossover study, 12 young (22 ± 2 years) healthy men consumed a beetroot juice (140 mL Beet-It Sport, James White Juice Company) that provided 12.9 mmol (0.8 g) of nitrate or placebo (nitrate-depleted Beet-It Sport) on 2 study visits. At 3 h postconsumption, brachial artery diameter, flow, and blood velocity were measured (Doppler ultrasound) at rest and during 6 exercise intensities. Nitrate supplementation raised plasma nitrate (19.5-fold) and nitrite (1.6-fold) concentrations, and lowered resting arterial pulse wave velocity (PWV) versus placebo (all p < 0.05), indicating absorption, conversion, and a biological effect of this supplement. The supplement-associated lowering of PWV was also negatively correlated with plasma nitrite (r = -0.72, p = 0.0127). Despite these systemic effects, nitrate supplementation had no effect on brachial artery diameter, flow, or shear rates at rest (all p ≥ 0.28) or during any exercise workload (all p ≥ 0.18). These findings suggest that acute dietary nitrate supplementation favorably modifies arterial PWV, but does not augment blood flow or brachial artery vasodilation during nonfatiguing forearm exercise in healthy young men.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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