Delayed Anaphylaxis to Red Meat Associated With Specific IgE Antibodies to Galactose
Wen L, Zhou J, Yin J, Sun JL, Sun Y, Wu K, Katial R
Allergy, asthma & immunology research · 10 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case report (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Emory University
- Government
- Foundation of National Epidemiology Study of Asthma and Allergies in China, sector fund of Ministry of Health of China
Based on 2 listed funder(s).
Publication
- Published
- 2014-12-19 · Allergy Asthma Immunol Res · vol. 7 · issue 1 · p. 92
- Cited
- 15 citations · more than 69% of similar papers · 0.7× the field average
- References
- 9 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Food Allergy and Anaphylaxis Research · Allergic Rhinitis and Sensitization · Contact Dermatitis and Allergies
- Keywords
- Immunoglobulin E, Anaphylaxis, Tick, Saliva, Immunology, Antibody, Biology, Primate, Medicine, Allergy, Virology, Biochemistry, Ecology
7 authors
From CN, BY, US
- Liping WenChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Junxiong ZhouChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Jia YinChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Jin‐Lu SunChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Yi Eve SunInstitute of Microbiology; Beijing Institute of Microbiology and Epidemiology
- Kai WuChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
Abstract
A novel delayed anaphylactic reaction to red meat, associated with tick bites and IgE antibodies against galactose-α-1, 3-galactose (α-gal), was reported in 2009 in the US, Australia and Europe. In this case, serum specific IgE to galactose-α-1, 3-galactose (>100 kU/L) and IgE to multiple non-primate mammalian proteins were positive. However, the pathogenesis of this disease remains unclear. We report the first case in Asia of delayed anaphylactic reaction to red meat, which was induced by bites from the hard tick, Hematophagous ixodidae. We confirmed the increased concentration of IgE reactive epitopes in non-primate mammalian organs, which may be rich in α-gal proteins in lymphatic and endothelial tissues. All confirmed ticks associated with this disorder in the literature and in our case belonged to the hard tick family. We hypothesize that hard tick saliva is enriched with blood-type substances, such as oligosaccharides, from the non-primate mammal victim's blood after days to weeks of blood sucking, which sensitizes humans through the injection route while blood sucking.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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