Effects of weight loss via high fat vs. low fat alternate day fasting diets on free fatty acid profiles
Varady KA, Dam VT, Klempel MC, Horne M, Cruz R, Kroeger CM, Santosa S
Scientific reports · 37 citations
How it was studied
- Design
- Controlled clinical trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Concordia University
- University or hospital
- University of Illinois at Urbana-Champaign
- Government
- Natural Sciences and Engineering Research Council of Canada
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2015-01-05 · Sci Rep · vol. 5 · issue 1 · p. 7561
- Publisher
- Nature Portfolio
- Cited
- 58 citations · more than 90% of similar papers · 2.8× the field average
- References
- 37 works
- Access
- Open access (journal) · CC-BY-NC-SA
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Diet, Metabolism, and Disease
- Keywords
- Triglyceride, Waist, Endocrinology, Weight loss, Internal medicine, Context (archaeology), Fatty acid, Composition (language), Chemistry, Low fat diet, Animal science, Cholesterol, Obesity, Medicine, Biology, Biochemistry
- MeSH
- humans, body weight, cholesterol, lipids, dietary fats, fatty acids, nonesterified, triglycerides, body mass index, fasting, body composition, adult, aged, middle aged, female, cholesterol, ldl, waist circumference
7 authors
From US, CA
- Krista A VaradyUniversity of Illinois Urbana-Champaign; University of Illinois Chicago
- Vi T. DamConcordia University; Concordia University; Concordia University
- Monica C KlempelConcordia University; Concordia University
- Matthew J. HorneConcordia University; Concordia University; Concordia University
- Rani CruzConcordia University; Concordia University; Concordia University
- Cynthia M. KroegerUniversity of Illinois Urbana-Champaign; University of Illinois Chicago
Abstract
Cardiovascular disease risk is associated with excess body weight and elevated plasma free fatty acid (FFA) concentrations. This study examines how an alternate-day fasting (ADF) diet high (HF) or low (LF) in fat affects plasma FFA profiles in the context of weight loss, and changes in body composition and lipid profiles. After a 2-week weight maintenance period, 29 women (BMI 30-39.9 kg/m(2)) 25-65 years old were randomized to an 8-week ADF-HF (45% fat) diet or an ADF-LF (25% fat) diet with 25% energy intake on fast days and ad libitum intake on feed days. Body weight, BMI and waist circumference were assessed weekly and body composition was measured using dual x-ray absorptiometry (DXA). Total and individual FFA and plasma lipid concentrations were measured before and after weight loss. Body weight, BMI, fat mass, total cholesterol, LDL-C and triglyceride concentrations decreased (P < 0.05) in both groups. Total FFA concentrations also decreased (P < 0.001). In the ADF-LF group, decreases were found in several more FFAs than in the ADF-HF group. In the ADF-HF group, FFA concentrations were positively correlated with waist circumference. Depending on the macronutrient composition of a diet, weight loss with an ADF diet decreases FFA concentrations through potentially different mechanisms.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-SA).
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