Effects of daily almond consumption on cardiometabolic risk and abdominal adiposity in healthy adults with elevated LDL-cholesterol: a randomized controlled trial
Berryman CE, West SG, Fleming JA, Bordi PL, Kris-Etherton PM
Journal of the American Heart Association · 72 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Industry funded
- University or hospital
- University of Pennsylvania
- University or hospital
- Pennsylvania State University
- University or hospital
- Deutsches Krebsforschungszentrum
- Government
- National Center for Research Resources
- Government
- NCRR NIH HHS
- Authors
- At least one author declares a financial tie to industry
- Grants
- National Center for Research Resources (M01 RR10732); National Center for Research Resources (M01-RR-010732)
Based on 5 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2015-01-05 · J Am Heart Assoc · vol. 4 · issue 1 · p. e000993
- Publisher
- Wiley
- Cited
- 114 citations · more than 97% of similar papers · 6.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 51 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Nuts composition and effects · Ginger and Zingiberaceae research · Peanut Plant Research Studies
- Keywords
- Medicine, Ldl cholesterol, Cholesterol, Randomized controlled trial, Abdominal obesity, Internal medicine, Metabolic syndrome, Endocrinology, Obesity
- MeSH
- humans, cardiovascular diseases, hypercholesterolemia, apolipoproteins, absorptiometry, photon, risk assessment, cross-over studies, reference values, adult, aged, middle aged, female, male, cholesterol, ldl, cholesterol, hdl, waist circumference, obesity, abdominal, healthy volunteers, prunus dulcis
5 authors
From US
- Claire E. BerrymanPennsylvania State University
- Sheila G. WestPennsylvania State University
- Jennifer A FlemingPennsylvania State University
- Peter L. BordiPennsylvania State University
- Penny M. Kris‐Etherton · correspondingPennsylvania State University
Abstract
Background
Evidence consistently shows that almond consumption beneficially affects lipids and lipoproteins. Almonds, however, have not been evaluated in a controlled-feeding setting using a diet design with only a single, calorie-matched food substitution to assess their specific effects on cardiometabolic risk factors.
Methods and results
In a randomized, 2-period (6 week/period), crossover, controlled-feeding study of 48 individuals with elevated LDL-C (149±3 mg/dL), a cholesterol-lowering diet with almonds (1.5 oz. of almonds/day) was compared to an identical diet with an isocaloric muffin substitution (no almonds/day). Differences in the nutrient profiles of the control (58% CHO, 15% PRO, 26% total fat) and almond (51% CHO, 16% PRO, 32% total fat) diets were due to nutrients inherent to each snack; diets did not differ in saturated fat or cholesterol. The almond diet, compared with the control diet, decreased non-HDL-C (-6.9±2.4 mg/dL; P=0.01) and LDL-C (-5.3±1.9 mg/dL; P=0.01); furthermore, the control diet decreased HDL-C (-1.7±0.6 mg/dL; P<0.01). Almond consumption also reduced abdominal fat (-0.07±0.03 kg; P=0.02) and leg fat (-0.12±0.05 kg; P=0.02), despite no differences in total body weight.
Conclusions
Almonds reduced non-HDL-C, LDL-C, and central adiposity, important risk factors for cardiometabolic dysfunction, while maintaining HDL-C concentrations. Therefore, daily consumption of almonds (1.5 oz.), substituted for a high-carbohydrate snack, may be a simple dietary strategy to prevent the onset of cardiometabolic diseases in healthy individuals.
Clinical trial registration url
www.clinicaltrials.gov; Unique Identifier: NCT01101230.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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