Caffeine intake from coffee or tea and cognitive disorders: a meta-analysis of observational studies
Kim YS, Kwak SM, Myung SK
Neuroepidemiology · 48 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2015-01-01 · Neuroepidemiology · vol. 44 · issue 1 · pp. 51–63
- Publisher
- Karger Publishers
- Cited
- 66 citations · more than 76% of similar papers · 1.1× the field average
- References
- 56 works
- Access
- Paywalled
- Research areas
- Coffee research and impacts · Tea Polyphenols and Effects · Heavy Metals in Plants
- Keywords
- Medicine, Meta-analysis, Dementia, Odds ratio, Confidence interval, Subgroup analysis, Relative risk, Cohort study, Epidemiology, Cognitive decline, Internal medicine, Observational study, Caffeine, Disease
- MeSH
- humans, dementia, alzheimer disease, caffeine, risk, case-control studies, cohort studies, cognition disorders, coffee, tea
3 authors
From KR
- Young Seok KimSeoul National University Hospital
- Sang Mi KwakKangbuk Samsung Hospital; Sungkyunkwan University
- Seung‐Kwon Myung
Abstract
Background
Observational epidemiological studies such as cross-sectional, case-control, and cohort studies have reported inconsistent findings regarding the association between caffeine intake from coffee or tea and the risk of cognitive disorders such as dementia, Alzheimer's disease, cognitive impairment, and cognitive decline.
Methods
We searched PubMed and EMBASE in September 2014. Three evaluators independently extracted and reviewed articles, based on predetermined selection criteria.
Results
Out of 293 articles identified through the search and bibliographies of relevant articles, 20 epidemiological studies from 19 articles, which involved 31,479 participants (8,398 in six cross-sectional studies, 4,601 in five case-control studies, and 19,918 in nine cohort studies), were included in the final analysis. The pooled odds ratio (OR) or relative risk (RR) of caffeine intake from coffee or tea for cognitive disorders (dementia, Alzheimer's disease, cognitive impairment, and cognitive decline) was 0.82 (95% confidence interval [CI], 0.67-1.01, I² = 63.2%) in a random-effects meta-analysis. In the subgroup meta-analysis by caffeine sources, the summary OR or RR of coffee intake was 0.83 (95% CI, 0.70-0.98; I² = 44.8%). However, in the subgroup meta-analysis by study design, the summary estimates (RR or OR) of coffee intake for cognitive disorders were 0.70 (95% CI, 0.50-0.98; I² = 42.0%) for cross-sectional studies, 0.82 (95% CI, 0.55-1.24; I² = 33.4%) for case-control studies, and 0.90 (95% CI, 0.59-1.36; I² = 60.0%) for cohort studies.
Conclusions
This meta-analysis found that caffeine intake from coffee or tea was not associated with the risk of cognitive disorders.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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