Funded in part by All Japan Coffee Association
Effect of caffeine contained in a cup of coffee on microvascular function in healthy subjects
Noguchi K, Matsuzaki T, Sakanashi M, Hamadate N, Uchida T, Kina-Tanada M, Kubota H, Nakasone J, Sakanashi M, Ueda S, Masuzaki H, Ishiuchi S, Ohya Y, Tsutsui M
Journal of pharmacological sciences · 41 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Industry group
- All Japan Coffee Association
- Government
- Japan Society for the Promotion of Science
- Government
- Japan Ministry of Education
- Grants
- Japan Society for the Promotion of Science (15H00594); Japan Society for the Promotion of Science (24590324)
Based on 3 listed funder(s).
Publication
- Published
- 2015-01-27 · J Pharmacol Sci · vol. 127 · issue 2 · pp. 217–222
- Publisher
- Elsevier BV
- Cited
- 63 citations · more than 96% of similar papers · 5.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 43 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Coffee research and impacts · Thermoregulation and physiological responses · Nutritional Studies and Diet
- Keywords
- Caffeine, Crossover study, Medicine, Reactive hyperemia, Placebo, Blood pressure, Blood flow, Ingestion, Heart rate, Cardiology, Anesthesia, Physiology, Internal medicine, Pathology
- MeSH
- fingers, endothelium, vascular, microcirculation, humans, caffeine, laser-doppler flowmetry, cross-over studies, double-blind method, placebo effect, blood pressure, regional blood flow, coffee, adult, female, male, young adult, healthy volunteers
14 authors
From JP
- Katsuhiko Noguchi · correspondingUniversity of the Ryukyus
- Toshihiro MatsuzakiUniversity of the Ryukyus
- Mayuko SakanashiUniversity of the Ryukyus
- Naobumi HamadateUniversity of the Ryukyus
- Taro UchidaUniversity of the Ryukyus
- Mika Kina-TanadaUniversity of the Ryukyus
Abstract
Recent epidemiological studies have demonstrated that coffee drinking is associated with reduced mortality of cardiovascular disease. However, its precise mechanisms remain to be clarified. In this study, we examined whether single ingestion of caffeine contained in a cup of coffee improves microvascular function in healthy subjects. A double-blind, placebo-controlled, crossover study was performed in 27 healthy volunteers. A cup of either caffeinated or decaffeinated coffee was drunk by the subjects, and reactive hyperemia of finger blood flow was assessed by laser Doppler flowmetry. In an interval of more than 2 days, the same experimental protocol was repeated with another coffee in a crossover manner. Caffeinated coffee intake slightly but significantly elevated blood pressure and decreased finger blood flow as compared with decaffeinated coffee intake. There was no significant difference in heart rate between caffeinated and decaffeinated coffee intake. Importantly, caffeinated coffee intake significantly enhanced post-occlusive reactive hyperemia of finger blood flow, an index of microvascular endothelial function, compared with decaffeinated coffee intake. These results provide the first evidence that caffeine contained in a cup of coffee enhances microvascular function in healthy individuals.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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