Magnesium intake and depression in adults
Tarleton EK, Littenberg B
Journal of the American Board of Family Medicine : JABFM · 60 citations
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- University of Vermont
Based on 1 listed funder(s).
Publication
- Published
- 2015-03-01 · J Am Board Fam Med · vol. 28 · issue 2 · pp. 249–256
- Publisher
- American Board of Family Medicine
- Cited
- 95 citations · more than 97% of similar papers · 6.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 94 works
- Access
- Free to read
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Aluminum toxicity and tolerance in plants and animals
- Keywords
- Medicine, National Health and Nutrition Examination Survey, Depression (economics), Confounding, Confidence interval, Magnesium, Population, Logistic regression, Relative risk, Internal medicine, Cross-sectional study, Environmental health
- MeSH
- humans, magnesium, nutrition surveys, incidence, risk factors, retrospective studies, cross-sectional studies, depression, dietary supplements, adult, aged, middle aged, vermont, female, male
2 authors
From US
- Emily K. TarletonUniversity of Vermont; University of Vermont Medical Center
- Benjamin LittenbergUniversity of Vermont; University of Vermont Medical Center
Abstract
Background
Depression is a common and often disabling disorder. Magnesium supplementation has been linked to improvement in depressive symptoms, but consensus on the relationship between magnesium and depression has not been reached.
Methods
The purpose of this study was to test the existence of an association between dietary magnesium intake and depression in the adult US population. A cross-sectional, population-based data set (National Health and Nutrition Examination Survey) was used to explore the relationship of magnesium intake and depression in 8894 US adults (mean age, 46.1 years; 47.4% men) from 2007 to 2010. Using logistic regression to model the relationship between the presence of depression (Patient Health Questionnaire score ≥5) and low magnesium intake (<184 mg/day), we examined the risk ratio (RR) of magnesium intake and its 95% confidence interval.
Results
After adjusting for all potential confounders, the strength of the association of very low magnesium intake with depression was statistically significant (RR = 1.16; 95% CI, 1.06-1.30). Adjusting for all other covariates, low magnesium intake was associated with depression in subjects younger than age 65 (RR, 1.22; 95% CI, 1.06-1.40; P = .007) but seemed to be protective in seniors (RR, 0.75; 95% CI, 0.56-0.98; P = .032).
Conclusions
We found a significant association between very low magnesium intake and depression, especially in younger adults. The finding of the potential protective effect of low magnesium intake in older adults is surprising and warrants further investigation.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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