Sleep is more sensitive to high doses of caffeine in the middle years of life
Robillard R, Bouchard M, Cartier A, Nicolau L, Carrier J
Journal of psychopharmacology (Oxford, England) · 40 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2015-03-10 · J Psychopharmacol · vol. 29 · issue 6 · pp. 688–697
- Publisher
- SAGE Publishing
- Cited
- 56 citations · more than 93% of similar papers · 4.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 51 works
- Access
- Paywalled
- Research areas
- Sleep and related disorders · Sleep and Wakefulness Research · Sleep and Work-Related Fatigue
- Keywords
- Caffeine, Polysomnography, Sleep (system call), Placebo, Slow-wave sleep, Middle age, Young adult, Sleep Stages, Anesthesia, Medicine, Sleep onset latency, Psychology, Sleep onset, Audiology, Internal medicine, Insomnia, Electroencephalography, Psychiatry, Apnea
- MeSH
- humans, caffeine, central nervous system stimulants, electroencephalography, cross-over studies, double-blind method, wakefulness, sleep, rem, adult, middle aged, female, male, young adult
5 authors
From CA
- Rébecca RobillardHôpital du Sacré-Cœur de Montréal; Canadian Sleep & Circadian Network
- Maude St-Cyr BouchardHôpital du Sacré-Cœur de Montréal; Canadian Sleep & Circadian Network
- Annick CartierHôpital du Sacré-Cœur de Montréal; Canadian Sleep & Circadian Network
- Laurence NicolauHôpital du Sacré-Cœur de Montréal; Canadian Sleep & Circadian Network
- Julie C CarrierInstitut Universitaire de Gériatrie de Montréal; Hôpital du Sacré-Cœur de Montréal; Canadian Sleep & Circadian Network; Université de Montréal
Abstract
During the middle years of life, sleep becomes more fragile and its sensitivity to psychostimulants may increase. This study evaluated the effects of 200 mg and 400 mg of caffeine on sleep in young and middle-aged adults. The sleep of 22 young (23.5 ± 1.9 years) and 24 middle-aged (51.7 ± 11.5 years) adults was recorded using polysomnography in two conditions (placebo and caffeine) in a double-blind cross-over design. Compared to placebo, caffeine increased sleep latency, shortened total sleep duration and reduced sleep efficiency. At the higher dose, these effects were more pronounced in middle-aged than in young adults. Furthermore, the higher dose of caffeine increased absolute stage 1 sleep in young adults, whereas it decreased absolute stage 2 sleep in middle-aged adults. Caffeine also induced dose-dependent increases in relative stage 1 sleep and reductions in absolute and relative slow wave sleep and absolute rapid eye movement sleep in both age groups. There was no dose- or age-related modulation of the effects of caffeine on quantified electroencephalographic measures. These results indicate that, compared to young adults, middle-aged adults are generally more sensitive to the effects of a high dose of caffeine on sleep quantity and quality.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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